Whole exome analysis reveals the genomic profiling related to chemo‐resistance in Chinese population with limited‐disease small cell lung cancer
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DOI: 10.1002/cam4.4950
Abstract: The mechanism of chemo‐resistance in small cell lung cancer (SCLC) is unclear. This study aims to explore the resistance‐related genomic profiles of residual tumors after neo‐adjuvant chemotherapy (NAC) in SCLC through the whole‐exome sequencing (WES). read more here.
Keywords: lung cancer; small cell; chemo resistance; resistance ... See more keywords
NORAD accelerates chemo-resistance of non-small-cell lung cancer via targeting at miR-129-1-3p/SOX4 axis
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DOI: 10.1042/bsr20193489
Abstract: Abstract Substantial researches indicated that long non-coding RNAs (lncRNAs) exerted profound effects on chemo-resistance in cancer treatment. Nonetheless, the role of NORAD in non-small-cell lung cancer (NSCLC) remains unclear. In the present study, we chose… read more here.
Keywords: chemo resistance; cancer; cell; mir 129 ... See more keywords
Family with sequence similarity 46 member a confers chemo-resistance to ovarian carcinoma via TGF-β/Smad2 signaling.
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DOI: 10.1080/21655979.2022.2064652
Abstract: Ovarian cancer is the most lethal malignancy with depressive 5-year survival rate, mainly due to patients with advanced stages experience tumor recurrence and resistance to the current chemotherapeutic agents. Thus, exploring the underlying molecular mechanisms… read more here.
Keywords: smad2; ovarian cancer; chemo resistance; cancer ... See more keywords
CD162 Is a Key E-Selectin Receptor Promoting Acute Myeloid Leukemia Chemo-Resistance in the Bone Marrow Niche
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DOI: 10.1182/blood-2019-132233
Abstract: We have recently found that the vascular adhesion molecule E(endothelial)-selectin is a critical bone marrow niche component mediating acute myeloid leukemia (AML) chemo-resistance. Clinical trials involving the use of E-selectin mimetics to improve efficacy of… read more here.
Keywords: chemo resistance; cd162; resistance; aml ... See more keywords
IGHG1 upregulation promoted gastric cancer malignancy via AKT/GSK-3β/β-Catenin pathway
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DOI: 10.1186/s12935-021-02098-1
Abstract: Background Despite current advances in gastric cancer treatment, disease metastasis and chemo-resistance remain as major hurdles against better overall prognosis. Previous studies indicated that IGHG1 as well as -Catenin serve as important regulators of tumor… read more here.
Keywords: chemo resistance; akt gsk; gastric cancer; gsk catenin ... See more keywords
Next-generation sequencing reveals mutations in RB1, CDK4 and TP53 that may promote chemo-resistance to palbociclib in ovarian cancer
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DOI: 10.1515/dmpt-2018-0027
Abstract: Abstract Because of the profound heterogeneity of ovarian cancer at the clinical, cellular and molecular levels, herein we discuss the molecular findings at the protein and genetic levels seen in our patient. Immunohistochemistry showed a… read more here.
Keywords: chemo resistance; resistance palbociclib; ovarian cancer; next generation ... See more keywords
Acute Myeloid Leukemia Chemo-Resistance Is Mediated by E-selectin Receptor CD162 in Bone Marrow Niches
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DOI: 10.3389/fcell.2020.00668
Abstract: The interactions of leukemia cells with the bone marrow (BM) microenvironment is critical for disease progression and resistance to treatment. We have recently found that the vascular adhesion molecule E-(endothelial)-selectin is a key niche component… read more here.
Keywords: chemo resistance; cd162; resistance; aml ... See more keywords
Role of Integrin β1 in the progression and chemo-resistance of esophageal squamous cell carcinoma
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DOI: 10.7150/jca.68647
Abstract: Objective: Integrins have been shown to play an important role in the tumorigenesis of many cancers. In this work, we aimed to explore the expression and clinical value of Integrin α5β1 in esophageal squamous cell… read more here.
Keywords: escc; integrin; expression; chemo resistance ... See more keywords