Sonoactivated Chemodynamic Therapy: A Robust ROS Generation Nanotheranostic Eradicates Multidrug‐Resistant Bacterial Infection
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DOI: 10.1002/adfm.202003587
Abstract: Although ultrasound‐based therapeutic strategies have achieved great success in the battle against antibiotic‐resistant bacterial infections, various sonodynamic treatments still suffer from poor therapeutic efficiency, failing to completely eradicate infections. Thus, more potent strategies are urgently… read more here.
Keywords: resistant bacterial; bacterial infection; chemodynamic therapy; infection ... See more keywords
Intracellular Mutual Promotion of Redox Homeostasis Regulation and Iron Metabolism Disruption for Enduring Chemodynamic Therapy
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DOI: 10.1002/adfm.202010390
Abstract: Intracellular redox homeostasis and the iron metabolism system in tumor cells are closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite extensive attempts, maintaining high levels of intracellular catalysts (free iron) and reactants… read more here.
Keywords: chemodynamic therapy; iron; redox homeostasis; iron metabolism ... See more keywords
Peroxidase‐Mimicking Iron‐Based Single‐Atom Upconversion Photocatalyst for Enhancing Chemodynamic Therapy
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DOI: 10.1002/adfm.202401893
Abstract: Chemodynamic therapy (CDT) has emerged as a novel approach to overcome cancer resistance and enhance anticancer efficacy. Despite the considerable effort devoted to current chemodynamic therapeutic agents, developing efficient delivery systems to induce ferroptosis remains… read more here.
Keywords: iron; based single; upconversion; chemodynamic therapy ... See more keywords
Intracellular Self‐Assembled Fe(II)‐Aniline Mustard NPs for Self‐Enhanced Anti‐Tumor Chemo‐/Chemodynamic Therapy
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DOI: 10.1002/adfm.202505343
Abstract: The combination of chemodynamic therapy (CDT) with chemotherapy amplifies antitumor effects while mitigating toxicity and overcoming tumor cell resistance associated with chemotherapy. However, small molecule chemo‐/chemodynamic therapy drugs are prone to rapid efflux, and nanomedicines… read more here.
Keywords: chemo chemodynamic; therapy; tumor; chemodynamic therapy ... See more keywords
An Organic Nanotherapeutic Agent Self-Assembled from Cyanine and Cu (II) for Combined Photothermal and Chemodynamic Therapy.
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DOI: 10.1002/adhm.202101008
Abstract: Although the combination of photothermal/chemodynamic therapy (PTT/CDT) based on various inorganic nanomaterials has promising anticancer effects, poor biocompatibility and biodegradability of inorganic nanoplatforms pose obstacles to their use in clinic. On the contrary, nanoscale metal-organic… read more here.
Keywords: organic nanotherapeutic; ptt cdt; chemodynamic therapy; photothermal chemodynamic ... See more keywords
Boosting Doxorubicin‐Induced Mitochondria Apoptosis for the Monodrug‐Mediated Combination of Chemotherapy and Chemodynamic Therapy
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DOI: 10.1002/adhm.202202045
Abstract: Doxorubicin (Dox)‐mediated generation of reactive oxygen radicals (ROS) for mitochondrial apoptosis is identified as a new cytotoxic mechanism in addition to the well‐established one via nuclear DNA replication interference. However, this mechanism contributes far less… read more here.
Keywords: apoptosis; dox; combination; doxorubicin ... See more keywords
RuCu Nanosheets with Ultra-high Nanozyme Activity for Chemodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300490
Abstract: Nanoenzymes have been widely explored for chemodynamic therapy (CDT) in cancer treatment. However, poor catalytic efficiency of nanoenzymes, especially in the tumor microenvironment with insufficient H2 O2 and mild acidity, limits the effect of CDT.… read more here.
Keywords: rucu nanosheets; catalytic efficiency; therapy; rucu nss ... See more keywords
Tumor‐Microenvironment‐Responsive Cerium‐Enriched Copper Nanozyme with O2 Supply and Oxidative Stress Amplification for In Situ Disulfiram Chemotherapy and Chemodynamic Therapy Intensification
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DOI: 10.1002/adhm.202303955
Abstract: Traditional chemotherapy has faced tough challenges of systemic toxicity, hypoxia resistance, and inadequacy of monotherapy. Developing the tumor‐specific O2‐supply‐enhanced chemotherapy without toxic drugs while combing other precise treatments can substantially improve therapeutic efficacy. Herein, a… read more here.
Keywords: oxidative stress; chemotherapy; tumor; supply ... See more keywords
Manganese-Dioxide-Coating-Instructed Plasmonic Modulation of Gold Nanorods for Activatable Duplex-Imaging-Guided NIR-II Photothermal-Chemodynamic Therapy.
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DOI: 10.1002/adma.202008540
Abstract: Nanotheranostic agents of gold nanomaterials in the second near-infrared (NIR-II) window have attracted significant attention in cancer management, owing to the reduced background signal and deeper penetration depth in tissues. However, it is still challenging… read more here.
Keywords: modulation; chemodynamic therapy; plasmonic modulation; dioxide ... See more keywords
A Glucose/Oxygen-Exhausting Nanoreactor for Starvation- and Hypoxia-Activated Sustainable and Cascade Chemo-Chemodynamic Therapy.
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DOI: 10.1002/smll.202000897
Abstract: Fenton reaction-mediated chemodynamic therapy (CDT) can kill cancer cells via the conversion of H2 O2 to highly toxic HO•. However, problems such as insufficient H2 O2 levels in the tumor tissue and low Fenton reaction… read more here.
Keywords: oxygen; nanoreactor; chemodynamic therapy; therapy ... See more keywords
Hollow Cuprous Oxide@Nitrogen-Doped Carbon Nanocapsules for Cascade Chemodynamic Therapy.
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DOI: 10.1002/smll.202107422
Abstract: Cuprous-based nanozymes have demonstrated great potential for cascade chemodynamic therapy (CDT) due to their higher catalytic efficiency and simple reaction conditions. Here, hollow cuprous oxide@nitrogen-doped carbon (HCONC) dual-shell structures are designed as nanozymes for CDT… read more here.
Keywords: cascade chemodynamic; carbon; hollow cuprous; cuprous oxide ... See more keywords