A chemoenzymatic approach enables the site‐specific conjugation of recombinant proteins
Sign Up to like & getrecommendations! Published in 2019 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201800528
Abstract: Many biotechniques including protein microarray, drug screening, biosensors rely on the immobilization of recombinant proteins on the solid supports. It is well known that random orientation of the immobilized proteins could impair their biologic functions.… read more here.
Keywords: site specific; site; specific conjugation; recombinant proteins ... See more keywords
Chemoenzymatic Approach toward the Synthesis of 3-O-(α/β)-Glucosylated 3-Hydroxy-β-lactams
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DOI: 10.1021/acsomega.8b01969
Abstract: Glycosylation significantly alters the biological and physicochemical properties of small molecules. β-Lactam alcohols comprise eligible substrates for such a transformation based on their distinct relevance in the chemical and medicinal community. In this framework, the… read more here.
Keywords: hydroxy lactams; toward synthesis; approach toward; synthesis ... See more keywords
Integrated Chemoenzymatic Approach to Streamline the Assembly of Complex Glycopeptides in the Liquid Phase.
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DOI: 10.1021/jacs.2c01819
Abstract: Glycosylation of proteins is a complicated post-translational modification. Despite the significant progress in glycoproteomics, accurate functions of glycoproteins are still ambiguous owing to the difficulty in obtaining homogeneous glycopeptides or glycoproteins. Here, we describe a… read more here.
Keywords: liquid phase; complex glycopeptides; integrated chemoenzymatic; approach ... See more keywords