Hybrid Chemoenzymatic Synthesis of C7‐Sugars for Molecular Evidence of in vivo Shikimate Pathway Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200241
Abstract: The design of distinctive chemical synthesis strategies aims for the most efficient routes towards versatile compounds in drug target studies. Here, we establish a powerful hybrid synthetic approach of total chemical and chemoenzymatic synthesis to… read more here.
Keywords: inhibition; vivo; synthesis; chemoenzymatic synthesis ... See more keywords
Chemoenzymatic Synthesis of O‐Containing Heterocycles from α‐Diazo Esters
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201901602
Abstract: The synergy of biocatalysis and transition metal catalysis is rapidly moving forward, providing increasingly effective workflows in chemical synthesis. Here we present a facile way to prepare synthetically challenging O‐containing heterocycles bearing disubstituted stereogenic centers… read more here.
Keywords: heterocycles diazo; synthesis containing; diazo esters; chemoenzymatic synthesis ... See more keywords
Chemoenzymatic Synthesis in Flow Reactors: A Rapid and Convenient Preparation of Captopril
Sign Up to like & getrecommendations! Published in 2017 at "ChemistryOpen"
DOI: 10.1002/open.201700082
Abstract: Abstract The chemoenzymatic flow synthesis of enantiomerically pure captopril, a widely used antihypertensive drug, is accomplished starting from simple, inexpensive, and readily available reagents. The first step is a heterogeneous biocatalyzed regio‐ and stereoselective oxidation… read more here.
Keywords: synthesis flow; chemoenzymatic synthesis; flow reactors; captopril ... See more keywords
Chemoenzymatic synthesis of fluorogenic phospholipids and evaluation in assays of phospholipases A, C and D.
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry and physics of lipids"
DOI: 10.1016/j.chemphyslip.2016.12.002
Abstract: Phospholipases are ubiquitous in nature and the target of significant research aiming at both their physiological roles and technical applications in e.g. the food industry. In the search for sensitive and selective phospholipase assays, we… read more here.
Keywords: synthesis fluorogenic; chemoenzymatic synthesis; fluorogenic phospholipids; phospholipids evaluation ... See more keywords
Chemoenzymatic Synthesis of Galectin Binding Glycopolymers.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00599
Abstract: Chemoenzymatic synthesis is an important strategy for the formation of glycopolymers. The use of a smaller number of traditional chemical steps and enzyme catalyzed reactions increases the yield of glycopolymer that can be produced by… read more here.
Keywords: functionalized dendrimers; galectin; nac functionalized; lac nac ... See more keywords
Chemoenzymatic Synthesis of 5-Methylpsilocybin: A Tryptamine with Potential Psychedelic Activity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00087
Abstract: A novel analogue of psilocybin was produced by hybrid chemoenzymatic synthesis in sufficient quantity to enable bioassay. Utilizing purified 4-hydroxytryptamine kinase from Psilocybe cubensis, chemically synthesized 5-methylpsilocin (2) was enzymatically phosphorylated to provide 5-methylpsilocybin (1).… read more here.
Keywords: chemoenzymatic synthesis; activity; synthesis methylpsilocybin; methylpsilocybin tryptamine ... See more keywords
Chemoenzymatic Synthesis of (+)-Xyloketal B.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00334
Abstract: Xyloketal B is a pentacyclic fungal marine natural product that has shown potential for the treatment of diseases such as Alzheimer's disease and atherosclerosis. Herein, we describe the first asymmetric synthesis of this natural product,… read more here.
Keywords: synthesis xyloketal; chemoenzymatic synthesis; synthesis;
Chemoenzymatic Synthesis of Novel Cytotoxic Epoxyketones Using the Eponemycin Biosynthetic Enzyme EpnF.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.3c00080
Abstract: Eponemycin is an α,β-epoxyketone natural product that inhibits the proteasome via covalent interaction of the epoxyketone warhead with catalytic N-terminal threonine residues. The epoxyketone warhead is biosynthesized from a β-ketoacid substrate by EpnF, a recently… read more here.
Keywords: synthesis novel; epoxyketones using; novel; novel cytotoxic ... See more keywords
Concise Chemoenzymatic Synthesis of Gedunin.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c09048
Abstract: The limonoids have attracted significant attention from the synthetic community owing to their striking structural complexity and medicinal potential. Recent efforts notwithstanding, synthetic access to many intact or ring D-seco limonoids still remains elusive. Here,… read more here.
Keywords: chemoenzymatic synthesis; synthesis gedunin; concise chemoenzymatic; synthesis ... See more keywords
Streamlined Chemoenzymatic Synthesis of Cyclic Peptides by Non-ribosomal Peptide Cyclases.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c11082
Abstract: Macrocyclization improves the pharmaceutical properties of peptides; however, regio- and chemoselective intramolecular cyclizations remain challenging. Here we developed a streamlined chemoenzymatic approach to synthesize cyclic peptides by exploiting non-ribosomal peptide (NRP) cyclases. Linear peptides linked… read more here.
Keywords: cyclic peptides; non ribosomal; ribosomal peptide; chemoenzymatic synthesis ... See more keywords
Streamlining the Chemoenzymatic Synthesis of Complex N-Glycans by a Stop and Go Strategy
Sign Up to like & getrecommendations! Published in 2018 at "Nature chemistry"
DOI: 10.1038/s41557-018-0188-3
Abstract: Contemporary chemoenzymatic approaches can provide highly complex multi-antennary N-linked glycans. These procedures are, however, very demanding and typically involve as many as 100 chemical steps to prepare advanced intermediates that can be diversified by glycosyltransferases… read more here.
Keywords: complex glycans; streamlining chemoenzymatic; multi antennary; chemoenzymatic synthesis ... See more keywords