Selenopeptide Nanomedicine Activates Natural Killer Cells for Enhanced Tumor Chemoimmunotherapy
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DOI: 10.1002/adma.202108167
Abstract: Chemoimmunotherapy using nanotechnology has shown great potential for cancer therapy in the clinic. However, uncontrolled transportation and synergistic responses remain challenges. Here, a self‐assembled selenopeptide nanoparticle that strengthens tumor chemoimmunotherapy through the activation of natural… read more here.
Keywords: tumor chemoimmunotherapy; natural killer; killer cells; chemoimmunotherapy ... See more keywords
A real‐world comparison between neoadjuvant chemoimmunotherapy and chemotherapy alone for resectable non‐small cell lung cancer
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DOI: 10.1002/cam4.4889
Abstract: The impact of neoadjuvant chemoimmunotherapy on pulmonary resection and related outcomes had been poorly reported in previous studies. The present study aims to clarify the efficacy and safety of neoadjuvant chemoimmunotherapy, and intraoperative difficulty in… read more here.
Keywords: non small; neoadjuvant chemoimmunotherapy; chemotherapy alone; chemoimmunotherapy ... See more keywords
A Dual-Targeting Liposome Enhances Triple-Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation.
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DOI: 10.1002/smll.202302834
Abstract: Immunotherapy gains increasing focus in treating triple-negative breast cancer (TNBC), while its efficacy is greatly restricted owing to low tumor immunogenicity and immunosuppressive tumor microenvironment (ITM). Herein, a LyP-1 and chondroitin sulfate (CS) dual-modified liposome… read more here.
Keywords: cell; stat3 activation; triple negative; chemoimmunotherapy ... See more keywords
Chemoimmunotherapy for the treatment of prostate cancer: Insights from mathematical modelling
Sign Up to like & getrecommendations! Published in 2021 at "Applied Mathematical Modelling"
DOI: 10.1016/j.apm.2020.09.021
Abstract: Abstract In this article, we aim to apply mathematical modelling by means of eight first-order ordinary differential equations to investigate the response of prostate cancer and the immune system to an allogenic whole-cell cancer vaccine… read more here.
Keywords: treatment; cancer; chemoimmunotherapy; prostate cancer ... See more keywords
Lung adenocarcinoma with ERBB2 exon 20 insertions: Comutations and immunogenomic features related to chemoimmunotherapy.
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DOI: 10.1016/j.lungcan.2021.07.014
Abstract: BACKGROUND The genomic mutation and immune feature landscape of ERBB2 exon 20 insertion (ERBB2-ex20ins)-driven non-small cell lung cancer and the features associated with the response to chemoimmunotherapy are currently unknown. METHODS The genomic landscape of… read more here.
Keywords: lung adenocarcinoma; chemoimmunotherapy; erbb2 exon; erbb2 ex20ins ... See more keywords
Tandem Chemoimmunotherapy by a Cascade-Responsive Molecular Prodrug.
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DOI: 10.1021/acschembio.1c00933
Abstract: The limited therapeutic effects of immunotherapy for most types of cancer stimulates the pursuit for efficient methods to improve its response rate. Herein we report the design and synthesis of a cascade-responsive molecular prodrug for… read more here.
Keywords: molecular prodrug; chemoimmunotherapy; prodrug; cascade responsive ... See more keywords
Neoadjuvant immunotherapy versus chemoimmunotherapy in non-small cell lung cancer: A protocol for systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033166
Abstract: Background: Worldwide, lung cancer is the most common cause of cancer morbidity and mortality. Non-small cell lung cancer (NSCLC) accounts for approximately 80 to 85% of all lung cancers. Recently, a few studies have reported… read more here.
Keywords: neoadjuvant immunotherapy; review; meta analysis; chemoimmunotherapy ... See more keywords
Impact of docetaxel plus ramucirumab in a second-line setting after chemoimmunotherapy in patients with non-small-cell lung cancer: A retrospective study.
Sign Up to like & getrecommendations! Published in 2021 at "Thoracic cancer"
DOI: 10.1111/1759-7714.14236
Abstract: BACKGROUND Chemoimmunotherapy has become a standard treatment option for patients with untreated advanced non-small-cell lung cancer (NSCLC). However, numerous patients with advanced NSCLC develop disease progression. Therefore, the selection of second-line treatment after chemoimmunotherapy is… read more here.
Keywords: docetaxel plus; cancer; chemoimmunotherapy; plus ramucirumab ... See more keywords
Functional status and therapy for older adults with diffuse large B-cell lymphoma in nursing homes: A population-based study.
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DOI: 10.1111/jgs.18302
Abstract: OBJECTIVES To characterize the prevalence of functional and cognitive impairments, and associations between impairments and treatment among older patients with diffuse large B cell lymphoma (DLBCL) receiving nursing home (NH) care. METHODS We used the… read more here.
Keywords: cell lymphoma; chemoimmunotherapy; large cell; functional cognitive ... See more keywords
Systemic inflammation is a determinant of outcomes of CD40 agonist–based therapy in pancreatic cancer patients
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DOI: 10.1172/jci.insight.145389
Abstract: Agonistic anti-CD40 monoclonal antibody (mAb) therapy in combination with chemotherapy (chemoimmunotherapy) shows promise for the treatment of pancreatic ductal adenocarcinoma (PDA). To gain insight into immunological mechanisms of response and resistance to chemoimmunotherapy, we analyzed… read more here.
Keywords: inflammation; chemoimmunotherapy; patients systemic; therapy ... See more keywords
Intratumoral CD8+ T cells as a potential positive predictor of chemoimmunotherapy response in PD-L1-negative advanced gastric cancer patients: a retrospective cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-22-644
Abstract: Background Previous studies have shown that PD-L1-positive advanced gastric cancer (GC) patients could achieve clinical benefit after receiving immune checkpoint inhibitors (ICI) in initial or subsequent therapy. A number of prospective studies such as Keynote-158… read more here.
Keywords: chemoimmunotherapy; cohort; intratumoral cd8; response ... See more keywords