Neoadjuvant Chemoradiotherapy vs Chemoimmunotherapy for Esophageal Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Surgery"
DOI: 10.1001/jamasurg.2025.0220
Abstract: Key Points Question Compared with neoadjuvant chemoradiotherapy (NCRT), is neoadjuvant chemoimmunotherapy (NCIT) associated with enhanced tumor regression and long-term survival in patients with locally advanced esophageal squamous cell carcinoma (ESCC)? Findings In this comparative effectiveness… read more here.
Keywords: neoadjuvant chemoradiotherapy; esophageal squamous; chemoimmunotherapy; squamous cell ... See more keywords
Selenopeptide Nanomedicine Activates Natural Killer Cells for Enhanced Tumor Chemoimmunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202108167
Abstract: Chemoimmunotherapy using nanotechnology has shown great potential for cancer therapy in the clinic. However, uncontrolled transportation and synergistic responses remain challenges. Here, a self‐assembled selenopeptide nanoparticle that strengthens tumor chemoimmunotherapy through the activation of natural… read more here.
Keywords: tumor chemoimmunotherapy; natural killer; killer cells; chemoimmunotherapy ... See more keywords
A real‐world comparison between neoadjuvant chemoimmunotherapy and chemotherapy alone for resectable non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4889
Abstract: The impact of neoadjuvant chemoimmunotherapy on pulmonary resection and related outcomes had been poorly reported in previous studies. The present study aims to clarify the efficacy and safety of neoadjuvant chemoimmunotherapy, and intraoperative difficulty in… read more here.
Keywords: non small; neoadjuvant chemoimmunotherapy; chemotherapy alone; chemoimmunotherapy ... See more keywords
Complex evaluation of serum immunoglobulin levels in patients with chronic lymphocytic leukemia: Significant increase in IgA after first‐line chemoimmunotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.7399
Abstract: The impact of chemoimmunotherapy (CIT) on immunoglobulin (Ig) quantities in patients with chronic lymphocytic leukemia (CLL) has not been extensively studied. read more here.
Keywords: immunoglobulin; patients chronic; chronic lymphocytic; chemoimmunotherapy ... See more keywords
A Dual-Targeting Liposome Enhances Triple-Negative Breast Cancer Chemoimmunotherapy through Inducing Immunogenic Cell Death and Inhibiting STAT3 Activation.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202302834
Abstract: Immunotherapy gains increasing focus in treating triple-negative breast cancer (TNBC), while its efficacy is greatly restricted owing to low tumor immunogenicity and immunosuppressive tumor microenvironment (ITM). Herein, a LyP-1 and chondroitin sulfate (CS) dual-modified liposome… read more here.
Keywords: cell; stat3 activation; triple negative; chemoimmunotherapy ... See more keywords
Chemoimmunotherapy for the treatment of prostate cancer: Insights from mathematical modelling
Sign Up to like & getrecommendations! Published in 2021 at "Applied Mathematical Modelling"
DOI: 10.1016/j.apm.2020.09.021
Abstract: Abstract In this article, we aim to apply mathematical modelling by means of eight first-order ordinary differential equations to investigate the response of prostate cancer and the immune system to an allogenic whole-cell cancer vaccine… read more here.
Keywords: treatment; cancer; chemoimmunotherapy; prostate cancer ... See more keywords
Lung adenocarcinoma with ERBB2 exon 20 insertions: Comutations and immunogenomic features related to chemoimmunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Lung cancer"
DOI: 10.1016/j.lungcan.2021.07.014
Abstract: BACKGROUND The genomic mutation and immune feature landscape of ERBB2 exon 20 insertion (ERBB2-ex20ins)-driven non-small cell lung cancer and the features associated with the response to chemoimmunotherapy are currently unknown. METHODS The genomic landscape of… read more here.
Keywords: lung adenocarcinoma; chemoimmunotherapy; erbb2 exon; erbb2 ex20ins ... See more keywords
Novel Indoleamine-2,3-Dioxygenase-Targeted Pt(IV) Prodrugs Regulate the Tumor Immune Microenvironment to Achieve Chemoimmunotherapy In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02116
Abstract: Convincing evidence revealed that some platinum-based drugs could stimulate immunological recognition, thereby inducing immunogenic cell death (ICD). Indoleamine-2,3-dioxygenase (IDO) is overexpressed in tumors, which caused exhaustion of tryptophan (T-cell energy) and constructed an immunosuppressive tumor… read more here.
Keywords: novel indoleamine; microenvironment; chemoimmunotherapy; tumor ... See more keywords
Ultrasound-Triggered NPC1L1-Targeting Nanobubbles for Remodeling the Tumor Microenvironment in Pancreatic Cancer Chemoimmunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.5c01194
Abstract: Abnormal cholesterol metabolism promotes the immunosuppressive microenvironment of pancreatic cancer and affects the long-term efficacy of chemotherapy drugs. Accurate diagnosis and targeted microenvironment-remodeling are challenging during the asymptomatic phase, considerably weakening the antitumor response. To… read more here.
Keywords: chemoimmunotherapy; microenvironment; tumor; pancreatic cancer ... See more keywords
Tandem Chemoimmunotherapy by a Cascade-Responsive Molecular Prodrug.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00933
Abstract: The limited therapeutic effects of immunotherapy for most types of cancer stimulates the pursuit for efficient methods to improve its response rate. Herein we report the design and synthesis of a cascade-responsive molecular prodrug for… read more here.
Keywords: molecular prodrug; chemoimmunotherapy; prodrug; cascade responsive ... See more keywords
Mature tertiary lymphoid structures linked to HPV status and anti-PD-1 based chemoimmunotherapy response in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Oncoimmunology"
DOI: 10.1080/2162402x.2025.2528109
Abstract: ABSTRACT Mature tertiary lymphoid structures (TLSs) are immune aggregates associated with immune checkpoint blockade (ICB) responses in various cancers, yet their role in chemoimmunotherapy response in head and neck squamous cell carcinoma (HNSCC) remains unclear.… read more here.
Keywords: tertiary lymphoid; response; chemoimmunotherapy; cell ... See more keywords