A comprehensive review of chemokine CXC17 (VCC1) in cancer, infection, and inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11846
Abstract: A crucial component of the immune system are chemokiness. Chemokine's dysregulation has been linked to a number of pathological diseases. Recently, CXCL17, a chemokine belonging to the CXC subfamily, was identified. With regard to a… read more here.
Keywords: chemokine; comprehensive review; chemokine cxc17; review chemokine ... See more keywords
Insight on the regulation of chemokine activities
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3mr0118-014r
Abstract: The activity of chemokines is regulated by several mechanisms that control the final cellular response. The present review discusses the complexity of the regulation of the chemokine system, and the novel findings describing how in… read more here.
Keywords: insight regulation; biology; regulation chemokine; chemokine activities ... See more keywords
Improved Methods for Quantifying Human Chemokine and Cytokine Biomarker Responses: Ultrasensitive ELISA and Meso Scale Electrochemiluminescence Assays.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9591-2_7
Abstract: ELISAs and similar immunoassays are a backbone of biomedical research and clinical practice. Here we review the major factors to consider in the development and application of ultrasensitive ELISAs for analysis of human immune responses… read more here.
Keywords: meso scale; elisa meso; improved methods; assays improved ... See more keywords
Comprehensive analysis of a chemokine- and chemokine receptor family-based signature for patients with lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-02944-1
Abstract: The clinical significance and comprehensive features of chemokines and their receptors in lung adenocarcinoma (LUAD) have not been clarified. We aimed to characterize the expression profiles of chemokine and chemokine receptor family members and construct… read more here.
Keywords: analysis; signature; chemokine chemokine; chemokine receptor ... See more keywords
Identification and Preparation of a Novel Chemokine Receptor-Binding Domain in the Cytoplasmic Regulator FROUNT
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biotechnology"
DOI: 10.1007/s12033-017-0002-2
Abstract: FROUNT is a cytoplasmic protein that binds to the membrane-proximal C-terminal regions (Pro-Cs) of chemokine receptors, CCR2 and CCR5. The FROUNT–chemokine receptor interactions play a pivotal role in the migration of inflammatory immune cells, indicating… read more here.
Keywords: frount; preparation novel; chemokine receptor; chemokine ... See more keywords
Purification of recombinant human chemokine CCL2 in E. coli and its function in ovarian cancer
Sign Up to like & getrecommendations! Published in 2021 at "3 Biotech"
DOI: 10.1007/s13205-020-02571-0
Abstract: Chemokine (CC-motif) ligand 2 (CCL2) is an inflammatory cytokine that regulates the infiltration and migration of monocytes. It is highly expressed by both tumor and stromal cells and has been associated with tumorigenesis. However, the… read more here.
Keywords: proliferation; ccl2; coli; ovarian cancer ... See more keywords
The inflammatory chemokine Cxcl18b exerts neutrophil‐specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2016.10.014
Abstract: ABSTRACT Cxcl18b is a chemokine found in zebrafish and in other piscine and amphibian species. Cxcl18b is a reliable inflammatory marker; however, its function is yet to be elucidated. Here, we found that Cxcl18b is… read more here.
Keywords: chemokine cxcl18b; cxcl18b; chemokine receptor; chemokine ... See more keywords
Genetic diversification of chemokine CXCL16 and its receptor CXCR6 in primates
Sign Up to like & getrecommendations! Published in 2018 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.04.005
Abstract: ABSTRACT Chemokine CXCL16 and its receptor CXCR6 are associated with a series of physiological and pathological processes in cooperative and stand‐alone fashions. To shed insight into their versatile nature, we studied genetic variations of CXCL16… read more here.
Keywords: cxcr6; diversification; receptor cxcr6; cxcl16 receptor ... See more keywords
Chemokine CXCb1 stimulates formation of NETs in trunk kidney neutrophils of common carp.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2019.103521
Abstract: Both in mammals and in fish, CXC chemokines activate leukocytes and regulate their migration both under normal physiological and inflammatory conditions. Moreover, in mammalian neutrophils CXC chemokines also stimulate the formation of neutrophil extracellular traps… read more here.
Keywords: trunk kidney; derived neutrophils; cxcb1; formation nets ... See more keywords
Dynamic Buffering of Extracellular Chemokine by a Dedicated Scavenger Pathway Enables Robust Adaptation during Directed Tissue Migration.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.01.013
Abstract: How tissues migrate robustly through changing guidance landscapes is poorly understood. Here, quantitative imaging is combined with inducible perturbation experiments to investigate the mechanisms that ensure robust tissue migration in vivo. We show that tissues exposed… read more here.
Keywords: extracellular chemokine; chemokine levels; tissue migration; migration ... See more keywords
Chemokine neutralization as an innovative therapeutic strategy for atopic dermatitis.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2016.11.023
Abstract: Atopic dermatitis is a chronic inflammatory skin disease with no specific treatment, affecting 15-30% of children and 2-10% of adults in developed countries. Current therapies alleviate symptoms and include emollients, glucocorticoids and calcineurin inhibitors. The… read more here.
Keywords: atopic dermatitis; receptor; chemokine; neutralization ... See more keywords