Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001335
Abstract: Background Amplification of the MYCN oncogene is a molecular hallmark of aggressive neuroblastoma (NB), a childhood cancer of the sympathetic nervous system. There is evidence that MYCN promotes a non-inflamed and T-cell infiltration-poor (‘cold’) tumor… read more here.
Keywords: neuroblastoma; interferon; chemokine expression; expression ... See more keywords
A Central Role for Heme Oxygenase-1 in the Control of Intestinal Epithelial Chemokine Expression
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Innate Immunity"
DOI: 10.1159/000488914
Abstract: In mucosal inflammatory disorders, the protective influence of heme oxygenase-1 (HO-1) and its metabolic byproducts, carbon monoxide (CO) and biliverdin, is a topic of significant interest. Mechanisms under investigation include the regulation of macrophage function… read more here.
Keywords: heme oxygenase; intestinal epithelial; expression; chemokine expression ... See more keywords
PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS‐driven ELR + CXC chemokine expression
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202216373
Abstract: The pathological retinal angiogenesis often causes blindness. Current anti‐angiogenic therapy for proliferative retinopathy targets the vascular endothelial growth factor (VEGF), but many patients do not radically benefit from this therapy. Herein, we report that circulating… read more here.
Keywords: cxc; pgf2; chemokine expression; ptgfr ... See more keywords