Heteromerization between α1B‐adrenoceptor and chemokine (C‐C motif) receptor 2 biases α1B‐adrenoceptor signaling: Implications for vascular function
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14463
Abstract: Previously, we reported that chemokine (C‐C motif) receptor 2 (CCR2) heteromerizes with α1B‐adrenoceptor (α1B‐AR) in leukocytes, through which α1B‐AR controls CCR2. Whether such heteromers are expressed in human vascular smooth muscle cells (hVSMCs) is unknown.… read more here.
Keywords: adrenoceptor; ccr2; chemokine motif; motif receptor ... See more keywords
Partial MHC/neuroantigen peptide constructs attenuate methamphetamine-seeking and brain chemokine (C-C motif) ligand 2 levels in rats.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173175
Abstract: There are no medications that target the neurotoxic effects or reduce the use of methamphetamine. Recombinant T-cell receptor ligand (RTL) 1000 [a partial major histocompatibility complex (pMHC) class II construct with a tethered myelin peptide],… read more here.
Keywords: chemokine motif; peptide; methamphetamine; motif ligand ... See more keywords
Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2016.09.042
Abstract: Inflammation is a central pathophysiologic mechanism that contributes to diabetes mellitus and diabetic nephropathy. Recently, we showed that macrophages directly contribute to diabetic renal injury and that pharmacological blockade or genetic deficiency of chemokine (C-C… read more here.
Keywords: chemokine motif; ccr2; renal injury; diabetic nephropathy ... See more keywords
Chemokine (C-X-C motif) ligand 1/chemokine (C-X-C motif) receptor 2 autocrine loop contributes to cellular proliferation, migration and apoptosis in cervical cancer
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DOI: 10.1080/21655979.2022.2036896
Abstract: ABSTRACT Cervical cancer is the most common malignant tumor in gynecology with high mortality rate, so novel approaches for cervical cancer treatment are urgently needed. In this study, we analyzed the gene expression data and… read more here.
Keywords: cervical cancer; chemokine motif; cancer; apoptosis cervical ... See more keywords
Chemokine (C‐C motif) ligand 25 expressed by trophoblast cells and leukocytes bearing its receptor Ccr9: An alliance during embryo implantation?
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.12783
Abstract: We hypothesized that trophoblast expression of Ccl25 attracts a specific leukocyte cell population to the implantation site for local regulation. read more here.
Keywords: chemokine motif; motif ligand; expressed trophoblast; ligand expressed ... See more keywords
Induction of chemokine (C‐C motif) ligand 5 by Epstein–Barr virus infection enhances tumor angiogenesis in nasopharyngeal carcinoma
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DOI: 10.1111/cas.13584
Abstract: Nasopharyngeal carcinoma (NPC) is etiologically associated with Epstein–Barr virus (EBV) infection and is known to be highly vascularized. Previous studies have suggested that EBV oncoproteins contribute to NPC angiogenesis. However, the regulatory network of EBV… read more here.
Keywords: chemokine motif; epstein barr; angiogenesis; infection ... See more keywords
Epigenetic regulation of chemokine (CC-motif) ligand 2 in inflammatory diseases.
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DOI: 10.1111/cpr.13428
Abstract: Appropriate responses to inflammation are conducive to pathogen elimination and tissue repair, while uncontrolled inflammatory reactions are likely to result in the damage of tissues. Chemokine (CC-motif) Ligand 2 (CCL2) is the main chemokine and… read more here.
Keywords: epigenetic regulation; chemokine motif; inflammatory; motif ligand ... See more keywords
Serum chemokine CC‐motif ligand 17 is a predictive marker of severe COVID‐19 in haemodialysis patients: A retrospective observational study
Sign Up to like & getrecommendations! Published in 2023 at "Nephrology"
DOI: 10.1111/nep.14151
Abstract: Maintenance haemodialysis (HD) patients are at higher risk for severe coronavirus disease 2019 (COVID‐19). Because of a limited number of facilities that can provide inpatient treatment for COVID‐19 and HD, it is important to identify… read more here.
Keywords: haemodialysis patients; severe covid; chemokine motif; marker severe ... See more keywords
Mechanism for Covalent Binding of MLN3126, an Oral Chemokine C-C Motif Receptor 9 Antagonist, to Serum Albumins
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.117.078782
Abstract: N-{4-Chloro-2-[(1-oxidopyridin-4-yl)carbonyl]phenyl}-4-(propan-2-yloxy)benzenesulfonamide (MLN3126) is an orally available chemokine C-C motif receptor 9 selective antagonist. In nonclinical pharmacokinetic studies of MLN3126, nonextractable radioactivity was observed in plasma after oral administration of 14C-labeled MLN3126 ([14C]MLN3126) to Sprague-Dawley (SD)… read more here.
Keywords: chemokine motif; covalent binding; mln3126; covalent ... See more keywords
Plasma Chemokine C-C Motif Ligand 2 as a Potential Biomarker for Prostate Cancer
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DOI: 10.2147/rru.s346978
Abstract: Purpose Serum levels of the polypeptide chemokine C-C motif ligand 2 (CCL2) have previously shown potential as a prostate cancer diagnostic and prognostic biomarker. Plasma CCL2 levels may be superior to serum levels as a… read more here.
Keywords: prostate cancer; serum; ccl2; chemokine motif ... See more keywords