Divergent chemokine receptor expression and the consequence for human IgG4 B cell responses.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of immunology"
DOI: 10.1002/eji.201948454
Abstract: IgG4 antibodies are unique to humans. IgG4 is associated with tolerance during immunotherapy in allergy, but also with pathology, as in pemphigus vulgaris and IgG4-related disease. Its induction is largely restricted to non-microbial antigens, and… read more here.
Keywords: igg4 cells; igg4; chemokine receptor; cell ... See more keywords
Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of toxicology"
DOI: 10.1007/s00204-021-03183-0
Abstract: Acetaminophen (APAP) is a widely used analgesic, but also a main cause of acute liver injury in the United States and many western countries. APAP hepatotoxicity is associated with a sterile inflammatory response as shown… read more here.
Keywords: cxcr2; cxcr2 hepatocytes; kupffer cells; chemokine receptor ... See more keywords
Comprehensive analysis of a chemokine- and chemokine receptor family-based signature for patients with lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-02944-1
Abstract: The clinical significance and comprehensive features of chemokines and their receptors in lung adenocarcinoma (LUAD) have not been clarified. We aimed to characterize the expression profiles of chemokine and chemokine receptor family members and construct… read more here.
Keywords: analysis; signature; chemokine chemokine; chemokine receptor ... See more keywords
Identification and Preparation of a Novel Chemokine Receptor-Binding Domain in the Cytoplasmic Regulator FROUNT
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biotechnology"
DOI: 10.1007/s12033-017-0002-2
Abstract: FROUNT is a cytoplasmic protein that binds to the membrane-proximal C-terminal regions (Pro-Cs) of chemokine receptors, CCR2 and CCR5. The FROUNT–chemokine receptor interactions play a pivotal role in the migration of inflammatory immune cells, indicating… read more here.
Keywords: frount; preparation novel; chemokine receptor; chemokine ... See more keywords
Membrane lipid environment: Potential modulation of chemokine receptor function
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.02.011
Abstract: HighlightsMembrane lipid composition influences chemokine receptor activity.Cholesterol is critical for chemokine binding, receptor stability & oligomerization.Tuning chemokine receptor signaling by lipids. ABSTRACT Migration of leukocytes is typically mediated by G protein‐coupled receptors (GPCRs) upon activation… read more here.
Keywords: receptor; chemokine receptor; activity; membrane lipid ... See more keywords
The inflammatory chemokine Cxcl18b exerts neutrophil‐specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2016.10.014
Abstract: ABSTRACT Cxcl18b is a chemokine found in zebrafish and in other piscine and amphibian species. Cxcl18b is a reliable inflammatory marker; however, its function is yet to be elucidated. Here, we found that Cxcl18b is… read more here.
Keywords: chemokine cxcl18b; cxcl18b; chemokine receptor; chemokine ... See more keywords
Non-redundant role of the chemokine receptor CX3CR1 in the anti-inflammatory function of gut macrophages.
Sign Up to like & getrecommendations! Published in 2017 at "Immunobiology"
DOI: 10.1016/j.imbio.2016.07.013
Abstract: Mucosal immunity at the intestinal level is constantly challenged by the presence of external food and microbial antigens and must be kept under strict control to avoid the rise of aberrant inflammation. Among cells of… read more here.
Keywords: anti inflammatory; cx3cr1; role; receptor ... See more keywords
CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.03.001
Abstract: Neutrophils are expanded and abundant in cancer-bearing hosts. Under the influence of CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factors produced by tumors, neutrophils, and granulocytic myeloid-derived suppressor cells (MDSCs) from cancer patients… read more here.
Keywords: cxcr1 cxcr2; receptor agonists; produced tumors; cytotoxicity ... See more keywords
Long-Range Coupled Motions Underlie Ligand Recognition by a Chemokine Receptor
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DOI: 10.1016/j.isci.2020.101858
Abstract: Summary Chemokines are unusual class-A G protein-coupled receptor agonists because of their large size (∼10 kDa) and binding at two distinct receptor sites: N-terminal domain (Site-I, unique to chemokines) and a groove defined by extracellular… read more here.
Keywords: recognition chemokine; ligand recognition; site; receptor ... See more keywords
Chemokine receptor gene polymorphisms and COVID-19: Could knowledge gained from HIV/AIDS be important?
Sign Up to like & getrecommendations! Published in 2020 at "Infection, Genetics and Evolution"
DOI: 10.1016/j.meegid.2020.104512
Abstract: Emerging results indicate that an uncontrolled host immune response, leading to a life-threatening condition called cytokine release syndrome (also termed “cytokine storm”), is the major driver of pathology in severe COVID-19. In this pandemic, considerable… read more here.
Keywords: receptor gene; gene polymorphisms; gained hiv; receptor ... See more keywords
Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.08.012
Abstract: Laura Martı́nez-Muñoz,* José Miguel Rodrı́guez-Frade, Rubén Barroso, Carlos Óscar S. Sorzano, Juan A. Torreño-Pina, César A. Santiago, Carlo Manzo, Pilar Lucas, Eva M. Garcı́a-Cuesta, Enric Gutierrez, Laura Barrio, Javier Vargas, Graciela Cascio, Yolanda R. Carrasco,… read more here.
Keywords: dependent chemokine; separating actin; actin dependent; nanoclustering dimerization ... See more keywords