Chemokines and Chemokine Receptors in the Development of NAFLD.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-8684-7_4
Abstract: Chemokines are chemo-attractants for leukocyte trafficking, growth, and activation in injured and inflammatory tissues. The chemokine system is comprised of 50 chemokine ligands and 20 cognate chemokine receptors. In the context of liver diseases, leukocytes,… read more here.
Keywords: development nafld; chemokine receptors; steatosis; chemokines chemokine ... See more keywords
Purification of native CCL7 and its functional interaction with selected chemokine receptors.
Sign Up to like & getrecommendations! Published in 2020 at "Protein expression and purification"
DOI: 10.1016/j.pep.2020.105617
Abstract: Chemokine receptors form a major sub-family of G protein-coupled receptors (GPCRs) and they are involved in a number of cellular and physiological processes related to our immune response and regulation. A better structural understanding of… read more here.
Keywords: selected chemokine; native ccl7; ccl7; purification native ... See more keywords
Maximal Unbiased Benchmarking Data Sets for Human Chemokine Receptors and Comparative Analysis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00004
Abstract: Chemokine receptors (CRs) have long been druggable targets for the treatment of inflammatory diseases and HIV-1 infection. As a powerful technique, virtual screening (VS) has been widely applied to identifying small molecule leads for modern… read more here.
Keywords: data sets; benchmarking data; mubd hcrs; maximal unbiased ... See more keywords
Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.9b00742
Abstract: CC chemokine receptors 2 (CCR2) and 5 (CCR5) are involved in many inflammatory diseases; however, most CCR2 and CCR5 clinical candidates have been unsuccessful. (Pre)clinical evidence suggests that dual CCR2/CCR5 inhibition might be more effective… read more here.
Keywords: triazolopyrimidinone derivatives; pharmacological evaluation; synthesis pharmacological; chemokine receptors ... See more keywords
The role of chemokines and chemokine receptors in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14826
Abstract: Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary artery remodelling leading to increased right ventricular pressure overload, which results in right heart failure and premature death. Inflammation plays a central role in the development… read more here.
Keywords: arterial hypertension; pulmonary arterial; role; chemokine receptors ... See more keywords
Identification of a conserved chemokine receptor motif that enables ligand discrimination
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abg7042
Abstract: Extensive ligand-receptor promiscuity in the chemokine signaling system balances beneficial redundancy and specificity. However, this feature poses a major challenge to selectively modulate the system pharmacologically. Here, we identified a conserved cluster of three aromatic… read more here.
Keywords: chemokine; discrimination; cluster; receptor ... See more keywords
The significance of chemokines in diffuse large B-cell lymphoma: a systematic review and future insights.
Sign Up to like & getrecommendations! Published in 2019 at "Future oncology"
DOI: 10.2217/fon-2018-0514
Abstract: Despite the progress made in molecular and clinical research, patients with diffuse large B-cell lymphoma (DLBCL) still have a bad prognosis. Recently, chemokines/chemokine receptors have become the subject of interest in relation to DLBCL. Studies… read more here.
Keywords: large cell; chemokine receptors; diffuse large; chemokines chemokine ... See more keywords
Targeting Chemokines and Chemokine Receptors in Melanoma and Other Cancers
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02480
Abstract: The tumor microenvironment is highly heterogeneous. It is composed of a diverse array of immune cells that are recruited continuously into lesions. They are guided into the tumor through interactions between chemokines and their receptors.… read more here.
Keywords: chemokine receptors; immune cells; chemokines chemokine; targeting chemokines ... See more keywords
Chemokines and chemokine receptors as promising targets in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1100869
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play important roles in RA development and pathogenesis. Biological therapies targeting… read more here.
Keywords: promising targets; receptors promising; chemokines chemokine; rheumatoid arthritis ... See more keywords
Chemokines and chemokine receptors in Behçet’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1109147
Abstract: Behçet’s disease (BD), a chronic vascular inflammatory disease, is characterized by the symptoms of ocular lesions, recurrent genital and oral ulcers, skin symptoms and arthritis in addition to neurological, intestinal and vascular involvement. The pathogenesis… read more here.
Keywords: beh disease; receptors beh; chemokines chemokine; disease ... See more keywords
Chemokines as Regulators of Neutrophils: Focus on Tumors, Therapeutic Targeting, and Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14030680
Abstract: Simple Summary Neutrophils are the main leukocyte subset present in human blood and play a fundamental role in the defense against infections. Neutrophils are also an important component of the tumor stroma because they are… read more here.
Keywords: regulators neutrophils; chemokines chemokine; chemokines regulators; chemokine receptors ... See more keywords