Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.04.078
Abstract: Motile cells navigate through complex tissue environments that include both attractive and repulsive cues. In response to tissue wounding, neutrophils, primary cells of the innate immune response, exhibit bidirectional migration that is orchestrated by chemokines… read more here.
Keywords: chemokine signaling; interstitial tissues; signaling regulation; migration ... See more keywords
Prenatal stress affects viability, activation, and chemokine signaling in astroglial cultures
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2017.08.006
Abstract: CXCL12/SDF-1α and CX3CL1/fractalkine are constitutively expressed in the brain, which indicates their significant functions. Emerging evidence highlights the role of astrocytes and the immune system in the pathophysiology of stress-related disorders. The aim of this… read more here.
Keywords: chemokine signaling; prenatal stress; stress affects; stress ... See more keywords
Chemokine Signaling in Allergic Contact Dermatitis: Toward Targeted Therapies.
Sign Up to like & getrecommendations! Published in 2018 at "Dermatitis"
DOI: 10.1097/der.0000000000000391
Abstract: Allergic contact dermatitis (ACD) is a common skin disease that results in significant cost and morbidity. Despite its high prevalence, therapeutic options are limited. Allergic contact dermatitis is regulated primarily by T cells within the… read more here.
Keywords: chemokine signaling; contact dermatitis; allergic contact;
Identification of a conserved chemokine receptor motif that enables ligand discrimination
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abg7042
Abstract: Extensive ligand-receptor promiscuity in the chemokine signaling system balances beneficial redundancy and specificity. However, this feature poses a major challenge to selectively modulate the system pharmacologically. Here, we identified a conserved cluster of three aromatic… read more here.
Keywords: chemokine; discrimination; cluster; receptor ... See more keywords
CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4384-8
Abstract: BackgroundProgrammed death-ligand 1 (PD-L1) is an immunosuppressor that plays an important role in cancer treatments. Although majority of the studies demonstrated that PD-L1 expression was regulated by cellular intrinsic and extrinsic controls, and IFN-γ was… read more here.
Keywords: cxcr3; chemokine signaling; gastric cancer; cxcl9 ... See more keywords
Determination of a prediction model for therapeutic response and prognosis based on chemokine signaling-related genes in stage I–III lung squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.921837
Abstract: Background: The chemokine signaling pathway plays an essential role in the development, progression, and immune surveillance of lung squamous cell carcinoma (LUSC). Our study aimed to systematically analyze chemokine signaling-related genes (CSRGs) in LUSC patients… read more here.
Keywords: risk group; risk; stage iii; chemokine signaling ... See more keywords
NF-κB Dependent Chemokine Signaling in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11101445
Abstract: Pancreatic cancer is one of the carcinomas with the worst prognoses, as shown by its five-year survival rate of 9%. Although there have been new therapeutic innovations, the effectiveness of these therapies is still limited,… read more here.
Keywords: chemokine signaling; tumor cells; pancreatic cancer; resistance ... See more keywords
Advances in Chemokine Signaling Pathways as Therapeutic Targets in Glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13122983
Abstract: Simple Summary Chemokine signaling is crucial for tumorigenesis, proliferation, angiogenesis, tumor progression and metastasis in glioblastoma. Furthermore, chemokines have an impact on the overall survival of GBM patients that, with a median survival of 15… read more here.
Keywords: advances chemokine; chemokine signaling; clinical studies; therapeutic targets ... See more keywords
Chemokine Signaling in Chemotherapy-Induced Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20122904
Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of chemotherapics such as taxanes, vinca alkaloids, and platinum compounds. In recent years, several reports have indicated the involvement of different molecular mechanisms in CIPN. The pathways… read more here.
Keywords: chemotherapy; chemokine signaling; induced neuropathic; neuropathic pain ... See more keywords