A Quantitative Chemoproteomic Platform to Monitor Selenocysteine Reactivity within a Complex Proteome.
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DOI: 10.1016/j.chembiol.2018.05.017
Abstract: Mammalian selenocysteine (Sec)-containing proteins, selenoproteins, are important to (patho)physiological processes, including redox homeostasis. Sec residues have been recalcitrant to mass spectrometry-based chemoproteomic methods that enrich for reactive cysteine (Cys) residues with electrophilic chemical probes, despite… read more here.
Keywords: sec; cys; chemoproteomic platform; reactivity ... See more keywords