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Published in 2021 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00065
Abstract: ConspectusOne of the biggest bottlenecks in modern drug discovery efforts is in tackling the undruggable proteome. Currently, over 85% of the proteome is still considered undruggable because most proteins lack well-defined binding pockets that can…
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Keywords:
chemoproteomic platforms;
undruggable proteome;
therapeutic modalities;
reimagining druggability ... See more keywords