Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.04.007
Abstract: Pharmacophore-focused chemical libraries are continuously being created in drug discovery programs, yet screening assays to maximize the usage of such libraries are not fully explored. Here, we report a chemical proteomics approach to reutilizing a… read more here.
Keywords: chemical library; focused chemical; chemoproteomic profiling; pharmacophore focused ... See more keywords
Chemoproteomic Profiling Maps Zinc-Dependent Cysteine Reactivity.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.3c00416
Abstract: As a vital micronutrient, zinc is integral to the structure, function, and signaling networks of diverse proteins. Dysregulated zinc levels, due to either excess intake or deficiency, are associated with a spectrum of health disorders.… read more here.
Keywords: chemoproteomic profiling; maps zinc; profiling maps; zinc ... See more keywords
Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00250
Abstract: Ethacrynic acid (EA) is a diuretic drug that is widely used to treat high-blood pressure and swelling caused by congestive heart failure or kidney failure. It acts through noncovalent inhibition of the Na+-K+-2Cl- cotransporter in… read more here.
Keywords: adenine nucleotide; mitochondrial function; nucleotide translocases; ethacrynic acid ... See more keywords