Chemoproteomics Reveals Unexpected Lysine/Arginine-Specific Cleavage of Peptide Chains as a Potential Protein Degradation Machinery.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b03237
Abstract: Proteins can undergo oxidative cleavage by in vitro metal-catalyzed oxidation (MCO) in either the α-amidation or the diamide pathway. However, whether oxidative cleavage of polypeptide-chain occurs in biological systems remains unexplored. We describe a chemoproteomic… read more here.
Keywords: protein; reveals unexpected; cleavage; chemoproteomics reveals ... See more keywords
Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Communications"
DOI: 10.1039/d3cc00577a
Abstract: Sofalcone (Sof), a synthetic analog of sophoradin, is a type of natural phenol derived from the traditional medicinal herb Sophora subprostrata, with potent anti-inflammatory activity. However, the mechanisms of action... read more here.
Keywords: inhibits inflammatory; inflammatory response; response caco; chemoproteomics reveals ... See more keywords