Analysis of Tumor Mutational Burden, Progression-Free Survival, and Local-Regional Control in Patents with Locally Advanced Non–Small Cell Lung Cancer Treated With Chemoradiation and Durvalumab
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DOI: 10.1001/jamanetworkopen.2022.49591
Abstract: Key Points Question Is tumor mutational burden (TMB) associated with outcomes among patients with locally advanced unresectable non–small cell lung cancer (NSCLC) treated with definitive chemoradiation and consolidative durvalumab? Findings In this cohort study of… read more here.
Keywords: locally advanced; free survival; durvalumab; progression free ... See more keywords
Long‐term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer
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DOI: 10.1002/cam4.1104
Abstract: The use of neoadjuvant chemotherapy or radiation for borderline resectable pancreatic adenocarcinoma (BL‐PDAC) is increasing. However, the impact of neoadjuvant chemotherapy and radiation therapy on the outcome of BL‐PDAC remains to be elucidated. We performed… read more here.
Keywords: chemotherapy; upfront chemotherapy; received upfront; neoadjuvant chemotherapy ... See more keywords
Adjuvant chemotherapy versus chemoradiation in high‐risk pancreatic adenocarcinoma: A propensity score‐matched analysis
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DOI: 10.1002/cam4.2491
Abstract: The American Society of Clinical Oncology guidelines recommend adjuvant chemoradiation (ACR) for margin‐positive (R1) and/or node‐positive (N+) pancreatic cancers. Our goal was to investigate if there is evidence of superiority of adjuvant chemoradiation (ACR) over… read more here.
Keywords: adjuvant chemotherapy; versus chemoradiation; chemotherapy versus; chemoradiation high ... See more keywords
Radiation pneumonitis in lung cancer patients treated with chemoradiation plus durvalumab
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DOI: 10.1002/cam4.3113
Abstract: Durvalumab after concurrent chemoradiation (cCRT) is now standard of care for unresected stage III non–small cell lung cancer (NSCLC). However, there is limited data on radiation pneumonitis (RP) with this regimen. Therefore, we assessed RP… read more here.
Keywords: patients treated; radiation pneumonitis; lung cancer; chemoradiation ... See more keywords
Neoadjuvant chemoradiation for esophageal cancer
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DOI: 10.1007/s00066-018-1261-y
Abstract: IntroductionTo retrospectively analyze the outcome of patients with esophageal cancer treated with neoadjuvant chemoradiation.MethodsA total of 41 patients received neoadjuvant intent chemoradiation for esophageal cancer. Most patients had a locally advanced disease (T3/4: 82%, N+: 83%, M0:… read more here.
Keywords: bei; fdg pet; der; chemoradiation ... See more keywords
Dysphagia and Oral Morbidities in Chemoradiation-Treated Head and Neck Cancer Patients
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DOI: 10.1007/s00455-018-9895-6
Abstract: This study prospectively evaluated relationships between oral morbidities and swallowing ability in head/neck cancer patients following chemoradiation therapy (CRT) and at 3 months following CRT. Thirty patients with confirmed head/neck cancer undergoing chemoradiation were assessed with… read more here.
Keywords: neck cancer; oral morbidities; chemoradiation; function ... See more keywords
Early initiation of chemoradiation may not influence survival of high-grade gliomas
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DOI: 10.1007/s11060-017-2633-3
Abstract: to biopsy only or different levels of partial resection could be less influenced by hypoxia and might be more prone to RT benefits. Conversely, the maximal safe resection is established as a predictor for longer… read more here.
Keywords: may influence; early initiation; initiation; initiation chemoradiation ... See more keywords
Chemoradiation in elderly patients with glioblastoma from the multi-institutional GBM-molRPA cohort: is short-course radiotherapy enough or is it a matter of selection?
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DOI: 10.1007/s11060-020-03468-x
Abstract: Background The optimal radiotherapy regimen in elderly patients with glioblastoma treated by chemoradiation needs to be addressed. We provide the results of a comparison between conventionally fractionated standard radiotherapy (CRT) and short-course radiotherapy (SRT) in… read more here.
Keywords: patients glioblastoma; radiotherapy; short course; elderly patients ... See more keywords
Lymphadenectomy and Survival After Neoadjuvant Chemoradiation for Esophageal Adenocarcinoma: Is More Better?
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DOI: 10.1007/s11605-020-04750-z
Abstract: The purpose of this study was to assess the impact of number of lymph nodes examined on survival in patients with esophageal adenocarcinoma who underwent neoadjuvant chemoradiation. The National Cancer Database was queried for patients… read more here.
Keywords: nodes months; esophageal adenocarcinoma; neoadjuvant chemoradiation; chemoradiation ... See more keywords
Long-term analysis of 2 prospective studies that incorporate mitomycin C into an adjuvant chemoradiation regimen for pancreatic and periampullary cancers
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DOI: 10.1016/j.adro.2017.07.008
Abstract: Purpose The purpose of this study was to report toxicity and long-term survival outcomes of 2 prospective trials evaluating mitomycin C (MMC) with 5-fluorouracil–based adjuvant chemoradiation in resected periampullary adenocarcinoma. Methods and materials From 1996… read more here.
Keywords: trial; periampullary cancers; long term; adjuvant chemoradiation ... See more keywords
Genomic Analyses for Predictors of Response to Chemoradiation in Stage III Non-Small Cell Lung Cancer
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DOI: 10.1016/j.adro.2020.10.027
Abstract: Background Radiation with platinum-based chemotherapy is the standard of care for unresectable stage III non-small cell lung cancer (NSCLC). Despite aggressive treatment, progression-free survival and overall survival remain poor. It is unclear whether any tumor… read more here.
Keywords: stage iii; response; non small; chemoradiation ... See more keywords