Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR‐Mediated Base Editors
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DOI: 10.1002/advs.202200717
Abstract: Selective inhibition of targeted protein kinases is an effective therapeutic approach for treatment of human malignancies, which interferes phosphorylation of cellular substrates. However, a drug‐imposed selection creates pressures for tumor cells to acquire chemoresistance‐conferring mutations… read more here.
Keywords: crispr mediated; functional phosphoproteomics; phosphorylation; chemoresistance ... See more keywords
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1‐Mediated NRF2 Ubiquitination
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DOI: 10.1002/advs.202204438
Abstract: Chemoresistance is the main obstacle in osteosarcoma (OS) treatment; however, the underlying mechanism remains unclear. In this study, it is discovered that DDRGK domain‐containing protein 1 (DDRGK1) plays a fundamental role in chemoresistance induced in… read more here.
Keywords: ddrgk1; ddrgk1 knockout; keap1; enhances osteosarcoma ... See more keywords
An Automatable Hydrogel Culture Platform for Evaluating Efficacy of Antibody-based Therapeutics in Overcoming Chemoresistance.
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DOI: 10.1002/biot.201900439
Abstract: The microenvironment plays a major role in conferring chemoresistance to cancer cells. In order to better inform clinical response to chemoresistance, preclinical models that recapitulate its hallmark features are needed to enable screening for resistance-specific… read more here.
Keywords: chemoresistance; efficacy; culture platform; platform ... See more keywords
Role of eIF4E on epithelial‐mesenchymal transition, invasion, and chemoresistance of prostate cancer cells
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DOI: 10.1002/cac2.12011
Abstract: Dear Editor, Prostate cancer (PCa) is the most common cancer and second leading cause of cancer death for men in the United States [1]. PCa with similar Gleason score has been reported to show substantial… read more here.
Keywords: chemoresistance; prostate cancer; pca; role eif4e ... See more keywords
Long non‐coding RNA PCAT6 targets miR‐204 to modulate the chemoresistance of colorectal cancer cells to 5‐fluorouracil‐based treatment through HMGA2 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1809
Abstract: Colorectal cancer (CRC) is still the third most common cancer in the world with a limited prognosis due to the chemoresistance of CRC cells to 5‐fluorouracil (5‐FU)‐based chemotherapy. In our previous study, we revealed that… read more here.
Keywords: chemoresistance; colorectal cancer; hmga2; crc ... See more keywords
CCL2 activates AKT signaling to promote glycolysis and chemoresistance in glioma cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cell biology international"
DOI: 10.1002/cbin.11778
Abstract: The incidence of gliomas is increasing. Although great progress in glioma treatment has been made, the clinical outcome remains unsatisfactory. Chemokine (C-C motif) ligand 2 (CCL2) plays a key role in different types of cancers,… read more here.
Keywords: glycolysis; chemoresistance; ccl2; glioma ... See more keywords
Targeting CXCR4 to suppress glioma‐initiating cells and chemoresistance in glioma
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DOI: 10.1002/cbin.11836
Abstract: Glioma initiating cells (GICs), also known as glioma stem cells, display the capacity to recapitulate the functional diversity within the tumor. Despite the great progress achieved over the last decades, defining the key molecular regulators… read more here.
Keywords: cxcr4; klf5; glioma initiating; glioma ... See more keywords
Exosomes derived from mesenchymal non‐small cell lung cancer cells promote chemoresistance
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DOI: 10.1002/ijc.30752
Abstract: Non‐small cell lung cancer (NSCLC) is the most common lung cancer type and the most common cause of mortality in lung cancer patients. NSCLC is often associated with resistance to chemotherapeutics and together with rapid… read more here.
Keywords: chemoresistance; exosomes derived; nsclc cells; lung cancer ... See more keywords
β1 Integrin is essential for fascin‐mediated breast cancer stem cell function and disease progression
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DOI: 10.1002/ijc.32183
Abstract: Breast cancer remains the second cause of tumor‐related mortality in women worldwide mainly due to chemoresistance and metastasis. The chemoresistance and metastasis are attributed to a rare subpopulation with enriched stem‐like characteristics, thus called Cancer… read more here.
Keywords: chemoresistance; breast cancer; fascin; expression ... See more keywords
Wnt/IL‐1β/IL‐8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5
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DOI: 10.1002/ijc.32419
Abstract: Malignant pleural mesothelioma (MPM) is a tumor with high chemoresistance and poor prognosis. MPM‐initiating cells (ICs) are known to be drug resistant, but it is unknown if and how stemness‐related pathways determine chemoresistance. Moreover, there… read more here.
Keywords: mpm; chemoresistance; mesothelioma; abcb5 ... See more keywords
Knockdown of LncRNA‐UCA1 suppresses chemoresistance of pediatric AML by inhibiting glycolysis through the microRNA‐125a/hexokinase 2 pathway
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DOI: 10.1002/jcb.26899
Abstract: Dysregulation of lncRNAs is implicated in chemoresistance in varieties of tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma‐associated 1 (UCA1) was reported to play an oncogenic role in AML. However, whether UCA1 was involved… read more here.
Keywords: glycolysis; chemoresistance; adr; aml ... See more keywords