Chemoselective Acylation of Hydrazinopeptides to Access Fluorescent Probes for Time-Resolved FRET Assays on GPCRs.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9121-1_7
Abstract: Fluorescence techniques represent a powerful tool to investigate dynamic and functional architecture of GPCRs. Thus, fluorescent GPCR ligands have found various applications in cellular imaging, in the development of binding assays as replacements for radioligands… read more here.
Keywords: fluorescent; acylation hydrazinopeptides; time resolved; access fluorescent ... See more keywords
Synthesis of diverse libraries of carboxamides via chemoselective N-acylation of amines by carboxylic acids employing Brønsted acidic IL [BMIM(SO3H)][OTf]
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DOI: 10.1016/j.tetlet.2019.151159
Abstract: Abstract Chemoselective N-acylation of amines with carboxylic acids as acyl electrophiles and Bronsted acidic IL [BMIM(SO3H)][OTf] as promoter is reported under both thermal and microwave irradiation to produce libraries of carboxamides in good to excellent… read more here.
Keywords: bmim so3h; amines carboxylic; carboxylic acids; acidic bmim ... See more keywords
Chemoselective acylation of 2-amino-8-quinolinol in the generation of C2-amides or C8-esters
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DOI: 10.1039/c7ra05287a
Abstract: Two different ways to carry out the chemoselective acylation of 2-amino-8-quinolinol with unique features to generate C2-amides or C8-esters were developed. The coupling reaction with a variety of carboxylic acids using EDCI and DMAP provided… read more here.
Keywords: amino; amides esters; acylation amino; amino quinolinol ... See more keywords
Chemoselective N-acylation of indoles using thioesters as acyl source
Sign Up to like & getrecommendations! Published in 2022 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.18.9
Abstract: The selective acylation of indoles often requires sensitive and reactive acyl chloride derivatives. Here, we report a mild, efficient, functional group tolerant, and highly chemoselective N-acylation of indoles using thioesters as a stable acyl source.… read more here.
Keywords: using thioesters; acyl source; indoles using; acylation indoles ... See more keywords