Chemoselective Bioconjugation of Amyloidogenic Protein Antigens to PEGylated Microspheres Enables Detection of α-Synuclein Autoantibodies in Human Plasma.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00530
Abstract: The misfolding and subsequent aggregation of amyloidogenic proteins is a classic pathological hallmark of neurodegenerative diseases. Aggregates of the α-synuclein protein (αS) are implicated in Parkinson's disease (PD) pathogenesis, and naturally occurring autoantibodies to these… read more here.
Keywords: oasis; chemoselective bioconjugation; oasis assay; plasma ... See more keywords
2H-Azirine-based Reagents for Chemoselective Bioconjugation at Carboxyl Residues inside Live Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b12116
Abstract: Protein modification by chemical reagents has played an essential role in the treatment of human diseases. However, the reagents currently used are limited to the covalent modification of cysteine and lysine residues. It is thus… read more here.
Keywords: reagents chemoselective; azirine based; based reagents; carboxyl residues ... See more keywords
Chemoselective bioconjugation based on modular click chemistry with 4-halocoumarins and aryl sulfonates
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DOI: 10.1039/d1ra03271b
Abstract: We report chemoselective and modular peptide bioconjugation using stoichiometric amounts of 4-halocoumarin and arylsulfonate agents that undergo metal-free C(sp2)-heteroatom bond formation at micromolar concentrations. The underlying ipso-substitution click chemistry is irreversible and generates stable and… read more here.
Keywords: chemoselective bioconjugation; bioconjugation; click chemistry; chemistry ... See more keywords