Highly Chemoselective and Enantioselective Synthesis of 3,4-2H-Pyrindin-2-ones by an NHC-Catalyzed [3 + 3] Cyclization.
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DOI: 10.1021/acs.orglett.0c00699
Abstract: A highly chemoselective and enantioselective cyclization of γ-chloroenals and ketimines has been developed to synthesize enantiopure 3,4-2H-pyrindin-2-ones as major products. It is proposed that the intermediate enone IV reacted with an enamine to proceed with… read more here.
Keywords: cyclization; chemoselective enantioselective; pyrindin ones; highly chemoselective ... See more keywords