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Published in 2019 at "ACS catalysis"
DOI: 10.1021/acscatal.9b02508
Abstract: Here we report a cytochrome P450 variant that catalyzes C2-amidation of 1-methylindoles with tosyl azide via nitrene transfer. Before evolutionary optimization the enzyme exhibited two undesired side reactivities resulting in reduction of the putative iron-nitrenoid…
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Keywords:
chemoselectivity;
chemoselectivity hemoprotein;
indole amidation;
engineering chemoselectivity ... See more keywords