Switching the chemoselectivity of perakine reductase for selective reduction of α,β-unsaturated ketones by Arg127 mutation.
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DOI: 10.1039/d3cc00850a
Abstract: The chemoselectivity of perakine reductase (PR) was engineered through rational design. We identified Arg127 as a control site of chemoselectivity. Mutation of Arg127 switched the chemoselectivity of PR between CO and CC or led to… read more here.
Keywords: perakine reductase; unsaturated ketones; chemoselectivity; chemoselectivity perakine ... See more keywords