Ex‐vivo drug testing predicts chemosensitivity in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5a0220-676rr
Abstract: The majority of acute myeloid leukemia (AML) patients will respond to standard chemotherapy, however, resistance is a prevalent problem contributing to incomplete responses, refractory disease, and ultimately patient death. Therefore, choosing more sensitive and effective… read more here.
Keywords: leukemia; acute myeloid; myeloid leukemia; chemosensitivity ... See more keywords
Suppressed Migration and Enhanced Cisplatin Chemosensitivity in Human Cancer Cell Lines by Tuning the Molecular Mobility of Supramolecular Biomaterials.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200438
Abstract: Cancer cells recognize physical cues transmitted from the surrounding microenvironment, and accordingly alter the migration and chemosensitivity. Cell adhesive biomaterials with tunable physical properties can contribute to the understanding of cancer cell responses, and development… read more here.
Keywords: cell; molecular mobility; mobility; chemosensitivity ... See more keywords
Inhibition of semaphorin 4D enhances chemosensitivity by increasing 5-fluorouracile-induced apoptosis in colorectal cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05761-4
Abstract: Overexpression of semaphorin 4D (SEMA4D), an immune semaphorin, is found in various human malignancies, including colorectal cancer (CRC). In this study, we explored the relationship between silencing SEMA4D expression and 5-fluorouracil (5-FU) response in the… read more here.
Keywords: sema4d; chemosensitivity; colorectal cancer; expression ... See more keywords
miR-485-5p suppresses breast cancer progression and chemosensitivity by targeting survivin.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.129
Abstract: Breast cancer is the most common cancer among women worldwide. Chemoresistance remains to be a considerable obstacle in breast cancer therapy and it is often involves dysregulation of a variety of microRNAs (miRNAs). miR-485-5p functions… read more here.
Keywords: mir 485; chemosensitivity; breast cancer; 485 suppresses ... See more keywords
GnT-V promotes chemosensitivity to gemcitabine in bladder cancer cells through β1,6 GlcNAc branch modification of human equilibrative nucleoside transporter 1.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.107
Abstract: Human equilibrative nucleoside transporter 1 (hENT1) transports nucleoside analogue drugs across cellular membranes and is necessary for the uptake of many anti-tumor drugs. Gemcitabine is a frontline agent of chemotherapy for bladder cancer despite its… read more here.
Keywords: bladder cancer; gemcitabine; chemosensitivity; cancer cells ... See more keywords
E‐Cadherin in Colorectal Cancer: Relation to Chemosensitivity
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Colorectal Cancer"
DOI: 10.1016/j.clcc.2018.10.003
Abstract: Micro‐Abstract We analyzed colorectal cancer chemosensitivity according to expression of the main epithelial–mesenchymal transition (EMT) marker, E‐cadherin. Human colon adenocarcinoma cell lines HT29 and HCT116 and 14 primary short‐term cultures from patient tumors were used.… read more here.
Keywords: term cultures; cell; chemosensitivity; colorectal cancer ... See more keywords
Synthesis, characterization and chemosensitivity studies of half-sandwich ruthenium, rhodium and iridium complexes containing к and к aroylthiourea ligands
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2018.11.020
Abstract: Abstract The reaction of [(p-cymene)RuCl2]2 and [Cp*MCl2]2 (M = Rh/Ir) metal precursors with aroylthiourea ligands (L1-L3) yielded a series of neutral mono-dentate complexes 1–9. The neutral mono-dentate coordination of aroylthiourea with metals via S atom was confirmed… read more here.
Keywords: mono dentate; synthesis characterization; chemosensitivity; aroylthiourea ligands ... See more keywords
Microwave-assisted β-cyclodextrin/chrysin inclusion complexation: An economical and green strategy for enhanced hemocompatibility and chemosensitivity in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.113257
Abstract: Abstract Chrysin (5, 7-dihydroxyflavone) (CHR), a wonder flavonoid that nature has bestowed upon us, is endowed with a broad spectrum of pharmacological properties. Nonetheless, the practical uses of CHR are greatly impeded owing to its… read more here.
Keywords: inclusion; chemosensitivity; chrysin; microwave assisted ... See more keywords
Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-022-00889-0
Abstract: Metabolic enzymes have an indispensable role in metabolic reprogramming, and their aberrant expression or activity has been associated with chemosensitivity. Hence, targeting metabolic enzymes remains an attractive approach for treating tumors. However, the influence and… read more here.
Keywords: panoptosis; oxaliplatin based; chemosensitivity; phosphorylated nfs1 ... See more keywords
MicroRNAs regulate key cell survival pathways and mediate chemosensitivity during progression of diffuse large B-cell lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "Blood Cancer Journal"
DOI: 10.1038/s41408-017-0033-8
Abstract: Despite better therapeutic options and improved survival of diffuse large B-cell lymphoma (DLBCL), 30–40% of the patients experience relapse or have primary refractory disease with a dismal prognosis. To identify biological correlates for treatment resistance,… read more here.
Keywords: cell; chemosensitivity; large cell; progression ... See more keywords
PARP inhibitor increases chemosensitivity by upregulating miR-664b-5p in BRCA1-mutated triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42319
Abstract: Emerging evidence has shown that adding poly(ADP-ribose) polymerase (PARP) inhibitors to chemotherapy regimens is superior to the control regimens alone in BRCA1-mutated triple-negative breast cancer (TNBC) patients, but their underlying mechanisms have not been fully… read more here.
Keywords: mir 664b; chemosensitivity; mutated triple; brca1 mutated ... See more keywords