DNA Morphology: Global Alteration of DNA Topological States Induced by Chemotherapeutic Agents and Its Implication in Cancer
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200715
Abstract: The dynamic topological states of chromosomal DNA regulate many cellular fundamental processes universally in all three domains of life, that is, bacteria, archaea, and eukaryotes. DNA‐binding proteins maintain the regional and global supercoiling of the… read more here.
Keywords: dna morphology; dna; dna binding; chemotherapeutic agents ... See more keywords
N‐Heterocyclic Carbene (NHC) Silver Complexes as Versatile Chemotherapeutic Agents Targeting Human Topoisomerases and Actin
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200345
Abstract: In recent years, the number of people suffering from cancer has risen rapidly and the World Health Organization and U.S. and European governments have identified this pathology as a priority issue. It is known that… read more here.
Keywords: carbene nhc; human topoisomerases; silver; chemotherapeutic agents ... See more keywords
Norepinephrine may be an underlying factor in chemobrain
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Cancer"
DOI: 10.1002/ijc.33548
Abstract: Dear Editor, Chemotherapy is a widely used and effective treatment for many types of neoplasms, but it is also frequently accompanied by psychological deficits that are referred to as chemotherapy-related cognitive impairment (CRCI), or colloquially… read more here.
Keywords: chemotherapy; crci; chemotherapeutic agents; noradrenergic signaling ... See more keywords
Nuclear Imaging for the Assessment of Cardiotoxicity from Chemotherapeutic Agents in Oncologic Disease
Sign Up to like & getrecommendations! Published in 2021 at "Current Cardiology Reports"
DOI: 10.1007/s11886-021-01493-4
Abstract: In this review, we summarize the major known cardiac toxicities of common chemotherapeutic agents and the role of nuclear cardiac imaging for the surveillance and assessment of cancer therapeutics–related cardiac dysfunction in routine clinical practice.… read more here.
Keywords: chemotherapeutic agents; therapeutics related; nuclear imaging; cardiotoxicity ... See more keywords
Recent advances in the chemistry of iron-based chemotherapeutic agents
Sign Up to like & getrecommendations! Published in 2020 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2020.213339
Abstract: Abstract The discovery of cisplatin followed by its success in anticancer therapy laid the foundation of metal-based drug design and development. Further research led to discovery of other platinum containing complexes, namely, carboplatin and oxaliplatin.… read more here.
Keywords: chemotherapeutic agents; based anticancer; chemistry; iron ... See more keywords
Cytotoxic chemotherapeutic agents and the EGFR-TKI osimertinib induce calreticulin exposure in non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Lung cancer"
DOI: 10.1016/j.lungcan.2021.03.018
Abstract: OBJECTIVES Synergistic anticancer efficacy of combination treatment with immune checkpoint inhibitors (ICIs) and platinum-based chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) may be attributable in part to the phenomenon of immunogenic cell… read more here.
Keywords: chemotherapeutic agents; cytotoxic chemotherapeutic; crt; lung cancer ... See more keywords
Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata.
Sign Up to like & getrecommendations! Published in 2020 at "Marine pollution bulletin"
DOI: 10.1016/j.marpolbul.2020.111493
Abstract: The consumption of anticancer agents has increased in the recent decades, and these substances may be present in sewage. Consequently, they may reach the environment when sanitation infrastructure is ineffective. This study evaluated the toxicity… read more here.
Keywords: mellita quinquiesperforata; agents using; assessment chemotherapeutic; chemotherapeutic agents ... See more keywords
Chemotherapeutic agents induce mitochondrial superoxide production and toxicity but do not alter respiration in skeletal muscle in vitro.
Sign Up to like & getrecommendations! Published in 2018 at "Mitochondrion"
DOI: 10.1016/j.mito.2017.10.010
Abstract: Chemotherapeutic agents (CAs) can independently promote skeletal muscle dysfunction, fatigue and wasting with mitochondrial toxicity implicated as a possible mechanism. Thus, we aimed to characterise the effects of various CAs on mitochondrial function, viability and… read more here.
Keywords: skeletal muscle; production; chemotherapeutic agents; toxicity ... See more keywords
Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2020.115117
Abstract: Solute carrier family 13 member 5 (SLC13A5) is an uptake transporter mainly expressed in the liver and transports citrate from blood circulation into hepatocytes. Accumulating evidence suggests that SLC13A5 is involved in hepatic lipogenesis, cell… read more here.
Keywords: response; chemotherapeutic agents; analysis; slc13a5 knockdown ... See more keywords
Hydrophilic Small Molecules That Harness Transthyretin To Enhance the Safety and Efficacy of Targeted Chemotherapeutic Agents.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00432
Abstract: The hydrophobicity of many chemotherapeutic agents usually results in their nonselective passive distribution into healthy cells and organs causing collateral toxicity. Ligand-targeted drugs (LTDs) are a promising class of targeted anticancer agents. The hydrophilicity of… read more here.
Keywords: chemotherapeutic agents; targeted chemotherapeutic; circulation half; efficacy ... See more keywords
Heparin Biofunctionalized Selenium Nanoparticles as Potential Antiangiogenic-Chemotherapeutic Agents for Targeted Doxorubicin Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c00219
Abstract: Combining antiangiogenic and chemotherapeutic agents has shown promising clinical benefits in cancer cures when the therapeutic intervention takes into account the tissue and molecular targets. Moreover, the risk of induced drug resistance is minimized when… read more here.
Keywords: dox; chemotherapeutic agents; hep; antiangiogenic chemotherapeutic ... See more keywords