Can curcumin along with chemotherapeutic drug and lipid provide an effective treatment of metastatic colon cancer and alter multidrug resistance?
Sign Up to like & getrecommendations! Published in 2019 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2019.109325
Abstract: Cancer is one of the most deadly diseases spreading all over the world and a major cause of fear in the society. Colon cancer is the 4th most common cancer causing death in both male… read more here.
Keywords: chemotherapeutic drug; drug; cancer cells; cancer ... See more keywords
Renal Clearable Quantum Dot-Drug Conjugates Modulate Labile Iron Species and Scavenge Free Radicals for Attenuating Chemotherapeutic Drug-Induced Acute Kidney Injury.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c00714
Abstract: Chemotherapeutic drug-induced acute kidney injury (AKI) involves pathologically increased labile iron species in the kidneys that mediate the excessive generation of reactive oxygen species (ROS) to induce ferroptosis and apoptosis, subsequently driving renal dysfunction. Herein,… read more here.
Keywords: drug induced; iron species; chemotherapeutic drug; labile iron ... See more keywords
The chemotherapeutic drug carboplatin affects macrophage responses to LPS and LPS tolerance via epigenetic modifications
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00955-7
Abstract: Following re-exposure to lipopolysaccharide (LPS), macrophages exhibit an immunosuppressive state known as LPS tolerance, which is characterized by repressed proinflammatory cytokine production. LPS-induced tolerance in macrophages is mediated in part by epigenetic changes. Carboplatin, an… read more here.
Keywords: epigenetic modifications; tolerance; lps tolerant; lps tolerance ... See more keywords
Inhibitory effects of oxali-Platin as a chemotherapeutic drug on the function and structure of bovine liver catalase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1581088
Abstract: Abstract Communicated by Ramaswamy H. Sarma read more here.
Keywords: effects oxali; inhibitory effects; chemotherapeutic drug; structure ... See more keywords
Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20408
Abstract: A critical problem in leukemia as well as other cancer therapies is the development of chemotherapeutic drug-resistance. We have developed models of hematopoietic drug resistance that are based on expression of dominant-negative TP53 [TP53 (DN)]… read more here.
Keywords: drug resistance; resistance; tp53; mek1 ... See more keywords
Cisplatin-chemotherapeutic Drug Interactions with the Surface of Some Metal Bioimplants in Physiological Serum
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Electrochemical Science"
DOI: 10.20964/2017.12.66
Abstract: The effect of cisplatin-chemotherapeutic drug (CisP), IUPAC name: azanide; dichloroplatinum(2+), on materials used as bioimplants, namely 304L stainless steel (SS) and titanium was investigated in physiological serum (PS) using the cyclic voltammetry, the potentiodynamic polarization… read more here.
Keywords: cisp; physiological serum; cisplatin chemotherapeutic; chemotherapeutic drug ... See more keywords
The efficacy of chemotherapeutic drug combinations may be predicted by concordance of gene response to the single agents
Sign Up to like & getrecommendations! Published in 2020 at "Oncology Letters"
DOI: 10.3892/ol.2020.12184
Abstract: Determining the expression of genes in response to different classes of chemotherapeutic drugs may allow for a better understanding as to which may be used effectively in combination. In the present study, the human colorectal… read more here.
Keywords: efficacy chemotherapeutic; response; expression; gene ... See more keywords
Degradation of P-glycoprotein by pristimerin contributes to overcoming ABCB1-mediated chemotherapeutic drug resistance in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Reports"
DOI: 10.3892/or.2016.5230
Abstract: ABCB1 (P-glycoprotein, ABCB1/MDR1) is one of the major members of the ABC transporters linked to MDR in cancer cells. In this study, we observed that pristimerin, a natural triterpenoid, potently decreased P-gp in a dose-dependent… read more here.
Keywords: drug resistance; overcoming abcb1; abcb1 mediated; drug ... See more keywords