The impact of actual body weight-based chemotherapy dosing and body size on adverse events and outcome in older patients with breast cancer: Results from Cancer and Leukemia Group B (CALGB) trial 49907 (Alliance A151436).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of geriatric oncology"
DOI: 10.1016/j.jgo.2017.11.007
Abstract: OBJECTIVE Actual weight-based (AWB) chemotherapy dosing is recommended for obese patients in the 2012 ASCO Clinical Practice Guideline. CALGB 49907, which utilized ABW-based adjuvant chemotherapy dosing, was a phase 3 trial in women ageā„65years with… read more here.
Keywords: chemotherapy; impact; breast cancer; cancer ... See more keywords
Current colorectal cancer chemotherapy dosing limitations and novel assessments to personalize treatments
Sign Up to like & getrecommendations! Published in 2022 at "Anz Journal of Surgery"
DOI: 10.1111/ans.18046
Abstract: Management of colorectal cancer is becoming increasingly more complex, with current major treatment modalities now including surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy. In the era of personalized oncology, a revised and more accurate method… read more here.
Keywords: body composition; chemotherapy dosing; colorectal cancer; chemotherapy ... See more keywords
Obesity, chemotherapy dosing, and toxicity: Results from the Optimal Breast Cancer Chemotherapy Dosing study.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.547
Abstract: 547 Background: ASCO guidelines state that most cytotoxic drugs should be dosed according to full body surface area (BSA) without limiting the dose on the basis of obesity. This approach is supported by a lack… read more here.
Keywords: breast cancer; obesity; chemotherapy; toxicity ... See more keywords
Assessing chemotherapy dosing strategies in a spatial cell culture model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.980770
Abstract: Predicting patient responses to chemotherapy regimens is a major challenge in cancer treatment. Experimental model systems coupled with quantitative mathematical models to calculate optimal dose and frequency of drugs can enable improved chemotherapy regimens. Here… read more here.
Keywords: cell; chemotherapy dosing; dosing strategies; model ... See more keywords