Genetic variants in p53 signaling pathway genes predict chemotherapy efficacy in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2215
Abstract: The murine double minute‐2 gene (MDM2) was originally identified as predicting chemotherapy efficacy. However, little is known regarding the association between single nucleotide polymorphisms (SNPs) in the p53 signaling pathway and prognosis/chemotherapy sensitivity in colorectal… read more here.
Keywords: chemotherapy; p53 signaling; colorectal cancer; signaling pathway ... See more keywords
Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response
Sign Up to like & getrecommendations! Published in 2019 at "Nature cell biology"
DOI: 10.1038/s41556-019-0298-1
Abstract: Recent studies have revealed a role for macrophages and neutrophils in limiting chemotherapy efficacy; however, the mechanisms underlying the therapeutic benefit of myeloid-targeting agents in combination with chemotherapy are incompletely understood. Here, we show that… read more here.
Keywords: chemotherapy; type interferon; cancer; chemotherapy efficacy ... See more keywords
Amentoflavone-loaded nanoparticles enhanced chemotherapy efficacy by inhibition of AKR1B10
Sign Up to like & getrecommendations! Published in 2022 at "Nanotechnology"
DOI: 10.1088/1361-6528/ac7810
Abstract: Therapeutic nanoparticles can be combined with different anticancer drugs to achieve a synergistic therapy and avoid the limitations of traditional medicine and thus have clinical prospects for cancer. Herein, an effective nanoplatform was developed for… read more here.
Keywords: enhanced chemotherapy; chemotherapy efficacy; adpf nps; drug ... See more keywords
Glutathione S-transferases genes variants and chemotherapy efficacy in gastrointestinal cancer patients: a meta-analysis based on 50 pharmacogenetic studies
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer"
DOI: 10.7150/jca.31130
Abstract: Background: The role of glutathione s-transferase genes (GSTP1, GSTM1 and GSTT1) variants and the GSTP1 expression level on chemotherapy efficacy of gastrointestinal cancer (GIC) patients were inconsistent. Methods: A meta-analysis about GSTP1, GSTM1 and GSTT1… read more here.
Keywords: gastrointestinal cancer; chemotherapy efficacy; cancer; efficacy gastrointestinal ... See more keywords