Basal‐like mammary carcinomas stimulate cancer stem cell properties through AXL‐signaling to induce chemotherapy resistance
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34429
Abstract: Basal‐like breast cancer (BLBC) is the most aggressive and heterogeneous breast cancer (BC) subtype. Conventional chemotherapies represent next to surgery the most frequently employed treatment options. Unfortunately, resistant tumor phenotypes often develop, resulting in therapeutic… read more here.
Keywords: cell; chemotherapy resistance; basal like; cancer stem ... See more keywords
Effect of long non-coding RNA H19 on oxidative stress and chemotherapy resistance of CD133+ cancer stem cells via the MAPK/ERK signaling pathway in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.143
Abstract: We explored the ability of a long non-coding RNA H19, to influence oxidative stress (OS) and chemotherapy resistance of CD133 + cancer stem cells via the MAPK/ERK signaling pathway in HCC. HCC tissues with corresponding adjacent normal… read more here.
Keywords: chemotherapy resistance; mapk; expression; cell ... See more keywords
Loss-of-function mutations in BCOR contribute to chemotherapy resistance in acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental hematology"
DOI: 10.1016/j.exphem.2021.07.005
Abstract: Primary refractory acute myeloid leukemia (AML) is unresponsive to conventional chemotherapy and has a poor prognosis. Despite the recent identification of novel driver mutations and advances in the understanding of the molecular pathogenesis, little is… read more here.
Keywords: chemotherapy; chemotherapy resistance; primary refractory; contribute chemotherapy ... See more keywords
Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Research"
DOI: 10.1016/j.scr.2018.01.016
Abstract: Background Colorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and is a leading cause of cancer-related death. Pre-clinical research of CRC liver metastasis predominately utilizes CRC cell lines grown in tissue culture.… read more here.
Keywords: chemotherapy resistance; crc; liver metastases; crc liver ... See more keywords
The role of MET in chemotherapy resistance
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-020-01577-5
Abstract: Chemotherapy remains the mainstay of treatment in the majority of solid and haematological malignancies. Resistance to cytotoxic chemotherapy is a major clinical problem and substantial research is ongoing into potential methods of overcoming this resistance.… read more here.
Keywords: chemotherapy resistance; resistance; met chemotherapy; role met ... See more keywords
MicroRNA34a is associated with chemotherapy resistance, metastasis, recurrence, survival, and prognosis in patient with osteosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030722
Abstract: Background: Osteosarcoma (OS) is the primary malignant bone tumor that most commonly affects children, adolescents, and young adults. MicroRNA-34a (miR-34a) is involved in tumor metastasis and may be a prognostic marker for patients with cancer.… read more here.
Keywords: metastasis; chemotherapy resistance; recurrence; mir 34a ... See more keywords
Correlative expression of exosomal miRNAs in chemotherapy resistance of triple-negative breast cancer: An observational study
Sign Up to like & getrecommendations! Published in 2024 at "Medicine"
DOI: 10.1097/md.0000000000038549
Abstract: Drug resistance in tumors is the primary contributor to clinical treatment failures, and aberrant expression of small RNA molecules, specifically microRNAs (miRNAs), in tumor tissues is intricately associated with drug resistance. The aim of this… read more here.
Keywords: resistance; chemotherapy resistance; negative breast; triple negative ... See more keywords
Downregulation of hsa‐miR‐548d‐3p and overexpression of HOXA9 in diffuse large B‐cell lymphoma patients and the risk of R‐CHOP chemotherapy resistance and disease progression
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13928
Abstract: Routine categorization of DLBCL patients into GCB and non‐GCB groups by Hans' criteria could not accurately predict chemotherapy resistance and disease progression in patients treated with standard R‐CHOP therapy. There is a need to identify… read more here.
Keywords: resistance disease; disease progression; chemotherapy resistance; chemotherapy ... See more keywords
Single‐cell transcriptome sequencing reveals SPP1‐CD44‐mediated macrophage–tumor cell interactions drive chemoresistance in TNBC
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.18525
Abstract: Triple‐negative breast cancer (TNBC) is often considered one of the most aggressive subtypes of breast cancer, characterized by a high recurrence rate and low overall survival (OS). It is notorious for posing challenges related to… read more here.
Keywords: single cell; chemotherapy resistance; cell interactions; cell ... See more keywords
Abstract LB-B22: TNBC kinase prioritization for targeted therapy after chemotherapy resistance
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-lb-b22
Abstract: Introduction: Triple negative breast cancer accounts for 10-15% of all breast cancers yet contribute to high recurrence and metastasis that leads to the death of patients. Lack of molecular therapeutic target for TNBC leaves the… read more here.
Keywords: chemotherapy; chemotherapy resistance; prioritization; kinase ... See more keywords
Abstract 1689: The role of circular RNAs in triple negative breast cancer and chemotherapy resistance
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1689
Abstract: Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related death among women worldwide. Triple negative breast cancer (TNBC) represents 15-20% of all breast cancers and is an aggressive subtype.… read more here.
Keywords: chemotherapy resistance; breast cancer; breast; cancer ... See more keywords