The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-019-03986-0
Abstract: Purpose Cancers are methionine (MET) and methylation addicted, causing them to be highly sensitive to MET restriction. The present study determined the efficacy of restricting MET with oral-recombinant methioninase (o-rMETase) and the DNA methylation inhibitor,… read more here.
Keywords: chemotherapy; combination; oral recombinant; chemotherapy resistant ... See more keywords
Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00248-x
Abstract: The adaptation of osteosarcoma cells to therapeutic pressure impedes the efficacy of chemotherapy for osteosarcoma. However, the characteristics and cellular organization of therapy-resistant cells in osteosarcoma tumors remain elusive. Here, we utilized single-cell transcriptomics to… read more here.
Keywords: osteosarcoma; stem like; chemotherapy resistant; therapy ... See more keywords
Abstract 6676: Exploratory biomarker analyses in phase 1 study of regorafenib, ipilimumab, and nivolumab (RIN) in chemotherapy resistant microsatellite stable (MSS) metastatic colorectal cancer (mCRC)
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DOI: 10.1158/1538-7445.am2023-6676
Abstract: Background: We recently reported an objective response rate of 36.4% in a phase I trial of RIN in MSS mCRC patients without liver metastases, while no response was noted in patients with liver metastases. Here… read more here.
Keywords: chemotherapy resistant; mcrc; rin; treatment ... See more keywords
Comprehensive genomic characterization of chemotherapy-resistant testicular germ cell tumors (TGCT).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.4555
Abstract: 4555Background: Although both seminomatous (Sem) and nonseminomatous (NS) TGCT have a favorable response to platinum-based chemotherapy (CT), a small proportion of them are chemorefractory. Therape... read more here.
Keywords: chemotherapy; comprehensive genomic; genomic characterization; characterization chemotherapy ... See more keywords
The Potential of Novel Lipid Agents for the Treatment of Chemotherapy-Resistant Human Epithelial Ovarian Cancer
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DOI: 10.3390/cancers14143318
Abstract: Simple Summary Disease recurrence and chemotherapy resistance are the major causes of mortality for the majority of epithelial ovarian cancer (EOC) patients. Standard of care relies on cytotoxic drugs that induce a form of cell… read more here.
Keywords: epithelial ovarian; ovarian cancer; chemotherapy resistant; chemotherapy ... See more keywords