Sacubitril/valsartan ameliorates cardiac function and ventricular remodeling in CHF rats via the inhibition of the tryptophan/kynurenine metabolism and inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-62472-7
Abstract: Sacubitril/valsartan has been highly recognized as a treatment for Chronic heart failure (CHF). Its potential cardioprotective benefits and mechanisms, however, remain to be explored. Metabolomics can be used to identify the metabolic characteristics and related… read more here.
Keywords: chf rats; sacubitril valsartan; tryptophan kynurenine; kynurenine metabolism ... See more keywords
HDAC3 impairs cardiac function in chronic heart failure rats via mediating microRNA-26b-3p to target high mobility group AT-hook 2.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666221006111339
Abstract: BACKGROUND Histone deacetylase 3 (HDAC3) has been studied in chronic heart failure (CHF), while the regulatory mechanism of HDAC3 on the development of CHF though regulating microRNA (miR)-26b-3p/high mobility group AT-hook 2 (HMGA2) axis has… read more here.
Keywords: mir 26b; 26b hmga2; hdac3; chf rats ... See more keywords