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   Articles with "chi3l1" as a keyword



Association of SNP‐SNP Interactions Between RANKL, OPG, CHI3L1, and VDR Genes With Breast Cancer Risk in Egyptian Women

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recommendations! Published in 2019 at "Clinical Breast Cancer"

DOI: 10.1016/j.clbc.2018.09.004

Abstract: Micro‐Abstract Genetic susceptibility for breast cancer (BC) is still poorly understood. We investigated the association of single nucleotide polymorphism (SNP)‐SNP interactions of 6 SNPs in RANKL, OPG, CHI3L1, and VDR genes with BC risk in… read more here.

Keywords: risk; vdr; chi3l1; vdr genes ... See more keywords

Chitinase 3‐like‐1 deficient donor splenocytes accentuated the pathogenesis of acute graft‐versus‐host diseases through regulating T cell expansion and type I inflammation

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recommendations! Published in 2017 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.03.010

Abstract: Abstract Acute graft‐versus‐host disease (aGVHD) is a major complication following transplantation, limiting the success of this therapy. Chitinase 3‐like‐1 (CHI3L1), a member of the glycosyl hydrolase 18 family, plays a critical role in bacterial infections,… read more here.

Keywords: expansion; chi3l1; pathogenesis; donor ... See more keywords

Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis

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recommendations! Published in 2017 at "Journal of Neuroimmunology"

DOI: 10.1016/j.jneuroim.2016.12.006

Abstract: Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS). Here, we investigated a potential association between CHI3L1 and the response to interferon-beta (IFNβ) and glatiramer acetate (GA). Serum CHI3L1 levels… read more here.

Keywords: chitinase like; response; interferon beta; chi3l1 ... See more keywords

Circulating CHI3L1 autoantibodies serve as a diagnostic biomarker in patients with obstructive sleep apnea

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-11537-2

Abstract: While polysomnography (PSG) is the gold standard for diagnosing obstructive sleep apnea (OSA), its limited availability means that many patients remain undiagnosed. This study seeks to evaluate whether CHI3L1-Ab could serve as a diagnostic biomarker… read more here.

Keywords: diagnostic biomarker; chi3l1; obstructive sleep; sleep apnea ... See more keywords

Functional study of the association of CHI3L1 polymorphisms with asthma susceptibility in the Southwest Chinese Han population

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recommendations! Published in 2019 at "Bioscience Reports"

DOI: 10.1042/bsr20182008

Abstract: Background: Chitinase 3-like 1 (CHI3L1) is involved in the Th2 cell mediated pathway, tissue remodeling and fibrosis. Correlations of CHI3L1 gene polymorphisms with asthma in previous studies have been inconsistent. The present study was designed… read more here.

Keywords: chinese han; association chi3l1; southwest chinese; association ... See more keywords

Characterization of Chitinase 3-like protein 1 spatiotemporal distribution in human post-traumatic brain contusions and other neuropathological scenarios.

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recommendations! Published in 2025 at "Journal of neuropathology and experimental neurology"

DOI: 10.1093/jnen/nlaf002

Abstract: Chitinase 3-like protein 1 (CHI3L1) is emerging as a promising biomarker for assessing intracranial lesion burden and predicting prognosis in traumatic brain injury (TBI) patients. Following experimental TBI, Chi3l1 transcripts were detected in reactive astrocytes… read more here.

Keywords: traumatic brain; brain; like protein; chitinase like ... See more keywords

PERSISTENT EXPRESSION OF CHITINASE 3-LIKE 1 IN EX VIVO-MAINTAINED GLIOBLASTOMA BIOPSIES DESPITE CHEMOTHERAPY: IMPLICATIONS FOR IMMUNE EVASION

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recommendations! Published in 2025 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaf185.075

Abstract: Background: Glioblastoma (GBM) remains a highly aggressive and treatment-resistant brain tumour, characterized by pro- found immune suppression. Chitinase 3-like 1 (CHI3L1), a cytokine implicated in tumour progression and im- mune modulation, has been associated with… read more here.

Keywords: persistent expression; expression chitinase; chitinase like; chi3l1 ... See more keywords

Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer

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recommendations! Published in 2024 at "eLife"

DOI: 10.1101/2023.10.03.560754

Abstract: The balanced gut microbiota in intestinal mucus layer plays an instrumental role in the health of the host. However, the mechanisms by which the host regulates microbial communities in the mucus layer remain largely unknown.… read more here.

Keywords: chi3l1; interaction; gut microbiota; mucus layer ... See more keywords

Chitinase‐3‐like protein 1 is an independent risk factor for the early failure of forearm autologous arteriovenous fistulas in uremic patients

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recommendations! Published in 2021 at "Therapeutic Apheresis and Dialysis"

DOI: 10.1111/1744-9987.13623

Abstract: Chitinase‐3‐like protein 1 (CHI3L1) has been introduced as a marker of inflammation in different diseases, which can promote cell proliferation and differentiation. It has also been demonstrated that elevated serum CHI3L1 concentration can independently predict… read more here.

Keywords: chitinase like; uremic patients; chi3l1; early failure ... See more keywords

SPINK5 is associated with early‐onset and CHI3L1 with late‐onset atopic dermatitis

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recommendations! Published in 2017 at "International Journal of Immunogenetics"

DOI: 10.1111/iji.12327

Abstract: We have recently showed that filaggrin (FLG) mutations are associated only with early‐onset of AD, but not with late‐onset of AD. Consequently, other susceptibility genes should receive attention, especially in patients with late‐onset of AD.… read more here.

Keywords: onset; late onset; early onset; associated early ... See more keywords

Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

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recommendations! Published in 2020 at "Science Translational Medicine"

DOI: 10.1126/scitranslmed.aax3519

Abstract: Chi3l1/YKL-40 is regulated by BMAL1 in astrocytes and influences AD pathogenesis in both mouse models and humans. Targeting astrocytes in AD Astrocytes and microglia play a dual role in Alzheimer’s disease (AD), increasing neuroinflammation and… read more here.

Keywords: alzheimer disease; chi3l1; chi3l1 ykl; expression ... See more keywords