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   Articles with "chi3l1" as a keyword



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Association of SNP‐SNP Interactions Between RANKL, OPG, CHI3L1, and VDR Genes With Breast Cancer Risk in Egyptian Women

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recommendations! Published in 2019 at "Clinical Breast Cancer"

DOI: 10.1016/j.clbc.2018.09.004

Abstract: Micro‐Abstract Genetic susceptibility for breast cancer (BC) is still poorly understood. We investigated the association of single nucleotide polymorphism (SNP)‐SNP interactions of 6 SNPs in RANKL, OPG, CHI3L1, and VDR genes with BC risk in… read more here.

Keywords: risk; vdr; chi3l1; vdr genes ... See more keywords
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Chitinase 3‐like‐1 deficient donor splenocytes accentuated the pathogenesis of acute graft‐versus‐host diseases through regulating T cell expansion and type I inflammation

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recommendations! Published in 2017 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.03.010

Abstract: Abstract Acute graft‐versus‐host disease (aGVHD) is a major complication following transplantation, limiting the success of this therapy. Chitinase 3‐like‐1 (CHI3L1), a member of the glycosyl hydrolase 18 family, plays a critical role in bacterial infections,… read more here.

Keywords: expansion; chi3l1; pathogenesis; donor ... See more keywords
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Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis

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recommendations! Published in 2017 at "Journal of Neuroimmunology"

DOI: 10.1016/j.jneuroim.2016.12.006

Abstract: Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS). Here, we investigated a potential association between CHI3L1 and the response to interferon-beta (IFNβ) and glatiramer acetate (GA). Serum CHI3L1 levels… read more here.

Keywords: chitinase like; response; interferon beta; chi3l1 ... See more keywords

Functional study of the association of CHI3L1 polymorphisms with asthma susceptibility in the Southwest Chinese Han population

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recommendations! Published in 2019 at "Bioscience Reports"

DOI: 10.1042/bsr20182008

Abstract: Background: Chitinase 3-like 1 (CHI3L1) is involved in the Th2 cell mediated pathway, tissue remodeling and fibrosis. Correlations of CHI3L1 gene polymorphisms with asthma in previous studies have been inconsistent. The present study was designed… read more here.

Keywords: chinese han; association chi3l1; southwest chinese; association ... See more keywords

Chitinase‐3‐like protein 1 is an independent risk factor for the early failure of forearm autologous arteriovenous fistulas in uremic patients

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recommendations! Published in 2021 at "Therapeutic Apheresis and Dialysis"

DOI: 10.1111/1744-9987.13623

Abstract: Chitinase‐3‐like protein 1 (CHI3L1) has been introduced as a marker of inflammation in different diseases, which can promote cell proliferation and differentiation. It has also been demonstrated that elevated serum CHI3L1 concentration can independently predict… read more here.

Keywords: chitinase like; uremic patients; chi3l1; early failure ... See more keywords

SPINK5 is associated with early‐onset and CHI3L1 with late‐onset atopic dermatitis

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recommendations! Published in 2017 at "International Journal of Immunogenetics"

DOI: 10.1111/iji.12327

Abstract: We have recently showed that filaggrin (FLG) mutations are associated only with early‐onset of AD, but not with late‐onset of AD. Consequently, other susceptibility genes should receive attention, especially in patients with late‐onset of AD.… read more here.

Keywords: onset; late onset; early onset; associated early ... See more keywords
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Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

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recommendations! Published in 2020 at "Science Translational Medicine"

DOI: 10.1126/scitranslmed.aax3519

Abstract: Chi3l1/YKL-40 is regulated by BMAL1 in astrocytes and influences AD pathogenesis in both mouse models and humans. Targeting astrocytes in AD Astrocytes and microglia play a dual role in Alzheimer’s disease (AD), increasing neuroinflammation and… read more here.

Keywords: alzheimer disease; chi3l1; chi3l1 ykl; expression ... See more keywords
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Chitinase 3-like 1 exacerbates cardiac dysfunction after myocardial infarction without alterations of neutrophil dynamics

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5733084

Abstract: Objective: Clinical studies show that chitinase 3-like 1 (CHI3L1) plasma level is a strong predictor of all-cause of mortality in patients with heart failure. Studies from our lab revealed that CHI3L1 is elevated in hearts… read more here.

Keywords: chil1; physiology; dysfunction; chil1 chil1 ... See more keywords
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The Modeling Analysis and Effect of CHI3L1 and CD31-Marked Microvessel Density in the Occurrence and Development of Cervical Squamous Cell Carcinoma

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recommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"

DOI: 10.1155/2022/3516335

Abstract: Background Chitinase-3-like protein 1 (CHI3Ll) has been identified as a novel tumor marker in several cancers. The objective of this study was to detect the expression of Chitinase-3-like protein 1 (CHI3L1) and CD31-labeled microvessel density… read more here.

Keywords: cscc; expression; chi3l1 cd31; chi3l1 ... See more keywords
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Abstract 323: CHI3L1 secreting PMN-MDSCs promote IFN-γ signaling in triple negative breast cancer

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-323

Abstract: BACKGROUND: Triple-negative breast cancer (TNBC) is highly malignant and has a poor prognosis because it lacks hormone therapy options. Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), a major component in tumor microenvironment are known to help the… read more here.

Keywords: pmn mdscs; breast cancer; tnbc; chi3l1 ... See more keywords

Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19.

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recommendations! Published in 2021 at "JCI insight"

DOI: 10.1172/jci.insight.148749

Abstract: COVID-19 is caused by SARS-CoV-2 (SC2) and is more prevalent and severe in elderly and patients with comorbid diseases (CM). Because chitinase 3-like-1 (CHI3L1) is induced during aging and CM, the relationships between CHI3L1 and… read more here.

Keywords: effects aging; chi3l1; chitinase like; therapeutic target ... See more keywords