Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis
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DOI: 10.1126/scitranslmed.aax3519
Abstract: Chi3l1/YKL-40 is regulated by BMAL1 in astrocytes and influences AD pathogenesis in both mouse models and humans. Targeting astrocytes in AD Astrocytes and microglia play a dual role in Alzheimer’s disease (AD), increasing neuroinflammation and… read more here.
Keywords: alzheimer disease; chi3l1; chi3l1 ykl; expression ... See more keywords