Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-08557-y
Abstract: Chicoric acid (CA) is a natural antioxidant with promising hepatoprotective activity. We investigated the potential of CA to prevent methotrexate (MTX) hepatotoxicity, pointing to the role of Nrf2/HO-1 signaling and PPARγ. Rats received CA for… read more here.
Keywords: ppar; stress inflammation; chicoric acid; nrf2 signaling ... See more keywords
Chicoric acid promotes glucose uptake and Akt phosphorylation via AMP-activated protein kinase α-dependent pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.05.020
Abstract: Abstract Chicoric acid is a naturally-occurring dicaffeoyl ester often found in chicory. Based on previous studies chicoric acid ameliorated insulin resistance in human hepatoma cells, the current study was undertaken to investigate the effects of… read more here.
Keywords: chicoric acid; protein kinase; glucose uptake; phosphorylation ... See more keywords
Chicoric Acid Attenuated Renal Tubular Injury in HFD-Induced Chronic Kidney Disease Mice through the Promotion of Mitophagy via the Nrf2/PINK/Parkin Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07795
Abstract: As the main factor in the pathogenesis of chronic kidney disease (CKD), the excessive apoptosis of renal tubular epithelial cells (RTECs) and its underlying mechanism of action are worth further investigation. Chicoric acid (CA), a… read more here.
Keywords: hfd; renal tubular; acid; chicoric acid ... See more keywords
The Bioactive Effects of Chicoric Acid As a Functional Food Ingredient.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal food"
DOI: 10.1089/jmf.2018.0211
Abstract: Chicoric acid, a hydroxycinnamic acid, has been reported to possess a variety of health benefits, including antivirus, antioxidant, anti-inflammation, obesity prevention, and neuroprotection effects. The purpose of this article is to summarize current knowledge of… read more here.
Keywords: effects chicoric; functional food; chicoric acid; food ingredient ... See more keywords
Chicoric Acid: Natural Occurrence, Chemical Synthesis, Biosynthesis, and Their Bioactive Effects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.888673
Abstract: Chicoric acid has been widely used in food, medicine, animal husbandry, and other commercial products because of its significant pharmacological activities. However, the shortage of chicoric acid limits its further development and utilization. Currently, Echinacea… read more here.
Keywords: chicoric acid; bioactive effects; acid; synthesis biosynthesis ... See more keywords
Structural-Guided Identification of Small Molecule Inhibitor of UHRF1 Methyltransferase Activity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.928884
Abstract: Ubiquitin-like containing plant homeodomain Ring Finger 1 (UHRF1) protein is recognized as a cell-cycle-regulated multidomain protein. UHRF1 importantly manifests the maintenance of DNA methylation mediated by the interaction between its SRA (SET and RING associated)… read more here.
Keywords: methylation; chicoric acid; sra domain; inhibitor ... See more keywords
C3H Expression Is Crucial for Methyl Jasmonate Induction of Chicoric Acid Production by Echinacea purpurea (L.) Moench Cell Suspension Cultures
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911179
Abstract: Echinacea purpurea (L.) Moench is one of the most economically important medicinal plants, cultivated worldwide for its high medicinal value and with several industrial applications in both pharmaceutical and food industries. Thanks to its various… read more here.
Keywords: purpurea moench; chicoric acid; echinacea purpurea; production ... See more keywords