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   Articles with "chidamide" as a keyword



Histone deacetylase inhibitor chidamide induces growth inhibition and apoptosis in NK/T lymphoma cells through ATM-Chk2-p53-p21 signalling pathway

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recommendations! Published in 2017 at "Investigational New Drugs"

DOI: 10.1007/s10637-017-0552-y

Abstract: SummaryWe investigated the anti-tumour effects and the underlying molecular mechanisms of a new oral histone deacetylase inhibitor (HDACi), chidamide, in NK/T cell lymphoma (NKTCL), a rare and highly aggressive non-Hodgkin lymphoma with poor outcomes. SNT-8… read more here.

Keywords: p53 p21; chidamide; lymphoma; chk2 p53 ... See more keywords
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CREBBP cooperates with the cell cycle machinery to attenuate chidamide sensitivity in relapsed/refractory diffuse large B-cell lymphoma.

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recommendations! Published in 2021 at "Cancer letters"

DOI: 10.1016/j.canlet.2021.09.002

Abstract: Diffuse large B-cell lymphoma (DLBCL) exhibits frequent inactivating mutations of the histone acetyltransferase CREBBP, highlighting the attractiveness of targeting CREBBP deficiency as a therapeutic strategy. In this study, we demonstrate that chidamide, a novel histone… read more here.

Keywords: relapsed refractory; chidamide; chidamide sensitivity; cell cycle ... See more keywords
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Chidamide stacked in magnetic polypyrrole nano-composites counter thermotolerance and metastasis for visualized cancer photothermal therapy

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recommendations! Published in 2022 at "Drug Delivery"

DOI: 10.1080/10717544.2022.2068697

Abstract: Abstract Photothermal therapy (PTT) has become one of the most promising therapies in cancer treatment as its noninvasiveness, high selectivity, and favorable compliance in clinic. However, tumor thermotolerance and distal metastasis reduce its efficacy, becoming… read more here.

Keywords: metastasis; chidamide; magnetic polypyrrole; thermotolerance ... See more keywords
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Chidamide Suppresses the Growth of Cholangiocarcinoma by Inhibiting HDAC3 and Promoting FOXO1 Acetylation

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recommendations! Published in 2022 at "Stem Cells International"

DOI: 10.1155/2022/3632549

Abstract: Inhibitors for histone deacetylases (HDACs) have been identified as epigenetic drug targets to treat a variety of malignancies through several molecular mechanisms. The present study is aimed at investigating the mechanism underlying the possible antitumor… read more here.

Keywords: foxo1 acetylation; chidamide; inhibiting hdac3; cca ... See more keywords
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Chidamide induces long-term remission in rare subcutaneous panniculitis-like T-cell lymphoma: An unusual case report and literature review

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recommendations! Published in 2021 at "International Journal of Immunopathology and Pharmacology"

DOI: 10.1177/20587384211009342

Abstract: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma composed of CD8+ cytotoxic T-cell that is primarily localized in the subcutaneous tissue. No standard treatments are currently available for SPTCL due to its… read more here.

Keywords: chidamide; panniculitis like; remission; subcutaneous panniculitis ... See more keywords

The Novel HDAC Inhibitor Chidamide Synergizes with Rituximab to Inhibit DLBCL Tumor Growth in Vitro and In Vivo By up-Regulating CD20 Expression

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recommendations! Published in 2018 at "Blood"

DOI: 10.1182/blood-2018-99-114598

Abstract: Background: Histone deacetylases (HDACs) are crucial proteins for supporting tumorigenesis. HDACs reverse chromatin acetylation and alter transcription of oncogenes and tumor suppressor genes by removing acetyl groups from histones. HDAC inhibitors are considered as promising… read more here.

Keywords: rituximab; chidamide; dlbcl; treatment ... See more keywords
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Initial Safety and Efficacy of Dose-Escalating HDACs Inhibitor Chidamide with VRD (Chi-VRD) Treatment for Newly-Diagnosed High-Risk Transplant Eligible Multiple Myeloma Patients

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-129434

Abstract: Background Deregulation of histone acetylation has been recognized to serve a critical role in the pathogenesis of multiple myeloma (MM), which histone deacetylase (HDACs) are overexpressed in plasma cells derived from patients with MM. Therefore,… read more here.

Keywords: chidamide; risk; high risk; treatment ... See more keywords
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Synergistic Antitumor Effect and Mechanism of Chidamide Combined with Gemcitabine, Oxaliplatin or Zanubrutinib in Diffuse Large B-Cell Lymphoma

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood-2020-133487

Abstract: Aims: To observe the synergistic antitumor effect of chidamide (a novel orally benzamide class of histone deacetylase inhibitors, HDACi) combined with gemcitabine, oxaliplatin or zanubrutinib (a second generation Bruton's tyrosine kinase (BTK) inhibitor) in diffuse… read more here.

Keywords: chidamide; cell lines; gemcitabine oxaliplatin; dlbcl cell ... See more keywords
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Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells

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recommendations! Published in 2017 at "Clinical Epigenetics"

DOI: 10.1186/s13148-017-0377-8

Abstract: BackgroundMany conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA… read more here.

Keywords: dna damage; chidamide; apoptosis; dna ... See more keywords

Effect of chidamide on treating hepatosplenic T-cell lymphoma: A case report

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recommendations! Published in 2020 at "World Journal of Clinical Cases"

DOI: 10.12998/wjcc.v8.i14.3122

Abstract: BACKGROUND Hepatosplenic T-cell lymphoma (HSTCL) is a rare subtype of non-Hodgkin’s lymphoma, which has an aggressive clinical course and an extremely poor prognosis. Chidamide is a novel, orally active, benzamide-type histone deacetylase (HDAC) inhibitor that… read more here.

Keywords: hepatosplenic cell; chidamide; report; cell lymphoma ... See more keywords

Ibrutinib combined with low-dose HDAC inhibitor chidamide synergistically enhances the anti-tumor effect in B-cell lymphoma.

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recommendations! Published in 2022 at "Hematological oncology"

DOI: 10.2139/ssrn.4022085

Abstract: Aberrant activity of histone deacetylases (HDACs) is frequently detected in B-cell lymphomas, which indicated the therapeutic implications of HDAC inhibitors for B-cell malignancies. We have discovered that lymphoma cells treated with HDAC inhibitor presented with… read more here.

Keywords: cell; anti tumor; chidamide; tumor ... See more keywords