G‐quadruplex ligands inhibit chikungunya virus replication
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27622
Abstract: Chikungunya virus (CHIKV) is a mosquito‐transmitted alphavirus affecting human health globally. G‐quadruplex secondary structures attract great attention as potential targets for antiviral strategy. In this study, we show that the CHIKV genome possesses several conserved… read more here.
Keywords: quadruplex sequences; chikungunya virus; replication; quadruplex ligands ... See more keywords
The relationship between chikungunya virus and the kidneys: A scoping review
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DOI: 10.1002/rmv.2357
Abstract: Several atypical forms of chikungunya fever (CHIK) have been described, including neurological, cardiac and renal involvement. These forms may be related to high morbidity and mortality rates. This scoping review based on the PubMed, Scopus,… read more here.
Keywords: scoping review; kidney; chikungunya virus; kidney injury ... See more keywords
Genome sequences of chikungunya virus isolates circulating in midwestern Brazil
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Virology"
DOI: 10.1007/s00705-019-04174-4
Abstract: Chikungunya virus (CHIKV) is a reemerging arbovirus of the family Togaviridae that causes CHIKV fever, a disease that can extend from weeks to years depending on whether clinical signs of arthralgia persist. CHIKV is mainly… read more here.
Keywords: chikv; circulating midwestern; chikungunya virus; isolates circulating ... See more keywords
Molecular characterization of chikungunya virus from the first cluster of patients during the 2020 outbreak in Chad.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of virology"
DOI: 10.1007/s00705-022-05427-5
Abstract: We sequenced a portion of the E1 envelope protein gene of two of four CHIKV RT-PCR-positive samples from the first cluster of chikungunya patients during the 2020 Chad outbreak. Phylogenetic analysis revealed that the viruses… read more here.
Keywords: characterization chikungunya; molecular characterization; first cluster; patients 2020 ... See more keywords
Characteristics of Chikungunya virus infection in patients with established rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Rheumatology"
DOI: 10.1007/s10067-020-05198-x
Abstract: The aim of this study is to describe both clinical and treatment needs in six patients who had a previous diagnosis of rheumatoid arthritis (RA) and were infected with Chikungunya virus (CHIKV). We report RA… read more here.
Keywords: infection; chikv infection; rheumatoid arthritis; chikungunya virus ... See more keywords
Neurologic Manifestation of Chikungunya Virus
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DOI: 10.1007/s11908-017-0561-1
Abstract: Purpose of ReviewChikungunya virus (CHIKV) is a RNA arbovirus that typically causes fevers and arthralgias, but reports of neurologic findings have become increasingly common. This article reviews our current understanding of CHIKV-associated neurologic manifestations.Recent FindingsIn… read more here.
Keywords: manifestation chikungunya; neurologic manifestation; chikv; disease ... See more keywords
Anti-viral Activities of Oroxylum indicum Extracts on Chikungunya Virus Infection
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DOI: 10.1007/s12088-017-0695-8
Abstract: Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus that poses a threat to human worldwide. Driven by the lack of approved medication and vaccination, research on anti-Chikungunya agents has received great attention. In an effort… read more here.
Keywords: anti viral; chikv; oroxylum indicum; indicum extracts ... See more keywords
Chikungunya virus infection induces differential inflammatory and antiviral responses in human monocytes and monocyte-derived macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "Acta tropica"
DOI: 10.1016/j.actatropica.2020.105619
Abstract: Chikungunya virus (CHIKV) is a zoonotic arthropod-borne virus that has caused several outbreaks in tropical and subtropical areas worldwide during the last 50 years. The virus is known to target different human cell types throughout… read more here.
Keywords: chikv; infection; monocyte derived; chikungunya virus ... See more keywords
Intraviral interactome of Chikungunya virus reveals the homo-oligomerization and palmitoylation of structural protein TF
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2019.04.098
Abstract: Abstract Chikungunya virus (CHIKV) is a re-emerging mosquito-transmitted RNA virus causing joint and muscle pain. Although the protein-protein interactions (PPIs) between nonstructural proteins of CHIKV have been extensively established, the complete CHIKV intraviral interactome remains… read more here.
Keywords: palmitoylation; homo oligomerization; chikv; intraviral interactome ... See more keywords
Seroprevalence of Chikungunya virus in blood donors from Northern and Southeastern Brazil
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DOI: 10.1016/j.htct.2018.04.002
Abstract: Background Chikungunya virus, an arbovirus that belongs to the Alphavirus genus of the Togaviridae family, causes a febrile illness accompanied by rash and arthralgia. It is estimated that during outbreaks, the prevalence of Chikungunya virus… read more here.
Keywords: blood donors; chikungunya virus; virus; brazil ... See more keywords
Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.05.007
Abstract: Chikungunya virus (CHIKV), a mosquito-borne pathogenic alphavirus is a growing public health threat. No vaccines or antiviral drug is currently available in the market for chikungunya treatment. nsP2pro, the viral cysteine protease, carries out an… read more here.
Keywords: protease; cysteine protease; structure; loop ... See more keywords