Inhibition of transient receptor potential vanilloid 1 (TRPV1) channel regulates chikungunya virus infection in macrophages
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Virology"
DOI: 10.1007/s00705-020-04852-8
Abstract: Chikungunya virus (CHIKV), a virus that induces pathogenic inflammatory host immune responses, is re-emerging worldwide, and there are currently no established antiviral control measures. Transient receptor potential vanilloid 1 (TRPV1), a non-selective Ca 2+ -permeable… read more here.
Keywords: trpv1; infection; inhibition; chikv infection ... See more keywords
Characteristics of Chikungunya virus infection in patients with established rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Rheumatology"
DOI: 10.1007/s10067-020-05198-x
Abstract: The aim of this study is to describe both clinical and treatment needs in six patients who had a previous diagnosis of rheumatoid arthritis (RA) and were infected with Chikungunya virus (CHIKV). We report RA… read more here.
Keywords: infection; chikv infection; rheumatoid arthritis; chikungunya virus ... See more keywords
Persistent Arthralgia and Related Risks Factors: A Cohort Study at 12 Months from Laboratory-Confirmed Chikungunya Infection.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of medical research"
DOI: 10.1016/j.arcmed.2018.04.008
Abstract: AIM OF THE STUDY To assess the cumulative incidence and clinical markers associated with persistent arthralgia (PA) at 12 months from acute chikungunya virus (CHIKV) infection. METHODS A multicenter retrospective cohort study was conducted in the… read more here.
Keywords: persistent arthralgia; infection; arthralgia related; chikv infection ... See more keywords
Immunoglobulin G Subclass Response After Chikungunya Virus Infection.
Sign Up to like & getrecommendations! Published in 2022 at "Viral immunology"
DOI: 10.1089/vim.2022.0055
Abstract: Various vaccines are under development to prevent chikungunya (CHIKV) infection. For the assessment of the CHIKV vaccine-induced antibody response, it is extremely important to understand antibody response after the infection has occurred. Previously, we assessed… read more here.
Keywords: chikungunya; chikv infection; infection; response ... See more keywords
Blunting CHIKV infection by keeping T cells in check
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aam6567
Abstract: Modulating the host immune response ameliorates arthritic disease in mice infected with chikungunya virus (Miner et al. and Teo et al.). Modulating the host immune response ameliorates arthritic disease in mice infected with chikungunya virus… read more here.
Keywords: medicine; blunting chikv; keeping cells; cells check ... See more keywords
DNA Damage Response Signaling Is Crucial for Effective Chikungunya Virus Replication
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01334-22
Abstract: Being intracellular parasites, viruses require several host cell machineries for effectively replicating their genome, along with virus-encoded enzymes. One of the strategies involves hijacking of the DDR pathways. ABSTRACT Viruses utilize a plethora of strategies… read more here.
Keywords: dna damage; chikv infection; infection; ddr pathways ... See more keywords
An E3 Ubiquitin Ligase Scaffolding Protein Is Proviral during Chikungunya Virus Infection in Aedes aegypti
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00595-22
Abstract: Arboviruses cause several diseases in humans and livestock. Vector control is the main strategy for controlling diseases transmitted by mosquitoes. ABSTRACT Chikungunya virus (CHIKV) is a reemerging alphavirus causing chikungunya disease (CHIKD) and is transmitted… read more here.
Keywords: chikv infection; replication; infection; chikungunya virus ... See more keywords
AB0913 Agreement study and expert consensus for the clinical picture of chikv infection
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.1882
Abstract: Background World Health Organization suggested case definitions to suspect and diagnose chikungunya virus infection which are: possible case, probable case and confirmed case. Although useful, when applied in practice, its lack definition for specific joint… read more here.
Keywords: agreement; chikv infection; arthritis; clinical criteria ... See more keywords
Vertical transmission of chikungunya virus: A systematic review
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DOI: 10.1371/journal.pone.0249166
Abstract: Objectives To describe and estimate the frequency of pregnancy outcomes, clinical and laboratory characteristics of vertical transmission of CHIKV in the neonate. Study design We performed a systematic review evaluating the clinical presentation of perinatally-acquired… read more here.
Keywords: transmission; systematic review; chikv infection; vertical transmission ... See more keywords
TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1139808
Abstract: Toll like receptor 4 (TLR4), a pathogen-associated molecular pattern (PAMP) receptor, is known to exert inflammation in various cases of microbial infection, cancer and autoimmune disorders. However, any such involvement of TLR4 in Chikungunya virus… read more here.
Keywords: host macrophages; chikv infection; infection; pro inflammatory ... See more keywords
A Novel Sphingosine Kinase Inhibitor Suppresses Chikungunya Virus Infection
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14061123
Abstract: Chikungunya virus (CHIKV) is a re-emerging arbovirus in the alphavirus genus. Upon infection, it can cause severe joint pain that can last years in some patients, significantly affecting their quality of life. Currently, there are… read more here.
Keywords: chikungunya virus; infection; chikv infection; inhibitor ... See more keywords