Key components of COPI and COPII machineries are required for chikungunya virus replication.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.142
Abstract: The infection of CHIKV is associated with cellular membranes; however whether early secretory pathways are involved in CHIKV replication remains unclear. In the present study, we have provided initial evidences that CHIKV requires both COPI… read more here.
Keywords: chikv replication; key components; replication; components copi ... See more keywords
Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya Virus nsP1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01747-18
Abstract: S-palmitoylation is an important form of lipid posttranslational modification, which affects the function of proteins by regulating their transport, stability, and localization. Previous studies have shown that FASN is critical for CHIKV replication; however, the… read more here.
Keywords: chikv replication; palmitoylation; fasn; nsp1 palmitoylation ... See more keywords
Inhibition of chikungunya virus replication by N-ω-Chloroacetyl-L-Ornithine in C6/36, Vero cells and human fibroblast BJ
Sign Up to like & getrecommendations! Published in 2023 at "Antiviral Therapy"
DOI: 10.1177/13596535231155263
Abstract: Background Polyamines are involved in several cellular processes and inhibiting their synthesis affects chikungunya virus (CHIKV) replication and translation, and, therefore, reduces the quantity of infectious viral particles produced. In this study, we evaluated the… read more here.
Keywords: human fibroblast; replication; vero cells; chikv replication ... See more keywords