Association Between Anesthesia Exposure and Neurocognitive and Neuroimaging Outcomes in Long-term Survivors of Childhood Acute Lymphoblastic Leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2019.1094
Abstract: Importance Limited studies have reported associations between anesthesia and neurocognitive and neuroimaging outcomes, particularly in pediatric patients who undergo multiple exposures to anesthesia as part of chronic disease management. Objective To investigate whether general anesthesia… read more here.
Keywords: childhood acute; long term; anesthesia; lymphoblastic leukemia ... See more keywords
Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.30857
Abstract: Large epidemiologic studies have reported the premature onset of age‐related conditions, such as ischemic heart disease and diabetes mellitus, in childhood cancer survivors, decades earlier than in their peers. The authors investigated whether young adult… read more here.
Keywords: childhood acute; young adult; adult survivors; lymphoblastic leukemia ... See more keywords
Genetic variation in the body mass index of adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort
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DOI: 10.1002/cncr.33258
Abstract: Treatment characteristics such as cranial radiation therapy (CRT) do not fully explain adiposity risk in childhood acute lymphoblastic leukemia (ALL) survivors. This study was aimed at characterizing genetic variation related to adult body mass index… read more here.
Keywords: childhood acute; body mass; mass index; lymphoblastic leukemia ... See more keywords
Infant feeding practices and childhood acute leukemia: Findings from the Childhood Cancer & Leukemia International Consortium
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DOI: 10.1002/ijc.34062
Abstract: Increasing evidence suggests that breastfeeding may protect from childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). However, most studies have limited their analyses to any breastfeeding, and only a few data have examined… read more here.
Keywords: leukemia international; international consortium; leukemia; childhood acute ... See more keywords
Influence of genetic variants in asparaginase pathway on the susceptibility to asparaginase-related toxicity and patients' outcome in childhood acute lymphoblastic leukemia
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DOI: 10.1007/s00280-021-04290-6
Abstract: Asparaginase (ASNase) is a key component in the treatment protocols of childhood acute lymphoblastic leukemia (ALL). Asparagine synthetase (ASNS) and the basic region leucine zipper activating transcription factor 5 (ATF5) mediate the anti-leukemic effect of… read more here.
Keywords: childhood acute; related toxicity; lymphoblastic leukemia; toxicity ... See more keywords
Secondhand smoke: A new and modifiable prognostic factor in childhood acute lymphoblastic leukemias.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental research"
DOI: 10.1016/j.envres.2019.108689
Abstract: BACKGROUND The 5-year overall survival (OS) in childhood acute lymphoblastic leukemia (ALL) has reached 90% in high-income countries, levels that can no be longer overcome with strategies based on intensification of treatment. Other approaches in… read more here.
Keywords: childhood acute; secondhand smoke; childhood; modifiable prognostic ... See more keywords
A systematic review and meta-analysis of the association between childhood infections and the risk of childhood acute lymphoblastic leukaemia
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DOI: 10.1038/bjc.2017.360
Abstract: Background:To determine whether childhood infections were associated with the development of childhood acute lymphoblastic leukaemia (ALL).Methods:We included studies that assessed any infection in childhood prior to the diagnosis of ALL in children aged 0–19 years… read more here.
Keywords: childhood acute; childhood; analysis; childhood infections ... See more keywords
Temporal changes in incidence of relapse and outcome after relapse of childhood acute lymphoblastic leukemia over three decades; a Nordic population-based cohort study
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DOI: 10.1038/s41375-022-01540-1
Abstract: Relapse remains the main obstacle to curing childhood acute lymphoblastic leukemia (ALL). The aims of this study were to compare incidence of relapse, prognostic factors, and survival after relapse between three consecutive Nordic Society of… read more here.
Keywords: outcome; childhood acute; relapse; incidence relapse ... See more keywords
FPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia
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DOI: 10.1038/s41598-020-69059-y
Abstract: Although the cure rate for childhood acute lymphoblastic leukemia (ALL) has exceeded 80% with contemporary therapy, relapsed ALL remains a leading cause of cancer-related death in children. Relapse-specific mutations can be identified by comprehensive genome… read more here.
Keywords: specific mutations; relapse specific; childhood acute; acute lymphoblastic ... See more keywords
Impact of TP53 gene variants on prognosis and survival of childhood acute lymphoblastic leukemia
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DOI: 10.1080/00365513.2023.2195682
Abstract: Abstract The tumor suppressor protein 53 (TP53) gene is one of the most studied genes in cancer. Although TP53 variants are rare events in acute leukemia, recent observations showed that relapse samples might harbor TP53… read more here.
Keywords: tp53 variants; tp53 gene; leukemia; childhood acute ... See more keywords
Early mortality continues to be a barrier to excellent survival in childhood acute promyelocytic leukemia: a retrospective study of 62 patients spanning 17 years
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2022.2082610
Abstract: Abstract Data on childhood acute promyelocytic leukemia (APL) from low-and middle-income countries is limited. Early mortality is a concern and often not highlighted in clinical trials. The retrospective study was conducted on patients (≤12 years) with… read more here.
Keywords: childhood acute; promyelocytic leukemia; mortality; early mortality ... See more keywords