Early child development in children who are HIV‐exposed uninfected compared to children who are HIV‐unexposed: observational sub‐study of a cluster‐randomized trial in rural Zimbabwe
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DOI: 10.1002/jia2.25456
Abstract: Exposure to maternal HIV may affect early child development (ECD), although previous studies have reported heterogeneous findings. We evaluated ECD among children who were HIV‐exposed uninfected (CHEU) and children who were HIV‐unexposed (CHU) recruited to… read more here.
Keywords: early child; exposed uninfected; children hiv; hiv unexposed ... See more keywords
Pharmacokinetics of once-daily darunavir/ritonavir in second-line treatment in African children with HIV
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DOI: 10.1093/jac/dkae319
Abstract: Abstract Background Darunavir is a potent HIV protease inhibitor with a high barrier to resistance. We conducted a nested pharmacokinetic sub-study within CHAPAS-4 to evaluate darunavir exposure in African children with HIV, taking once-daily darunavir/ritonavir… read more here.
Keywords: african children; darunavir; ritonavir second; children hiv ... See more keywords
Children who are HIV-exposed and uninfected: evidence for action.
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DOI: 10.1097/qad.0000000000003409
Abstract: Prior to widespread availability of antiretroviral therapy (ART) in sub-Saharan Africa, children who were HIV-exposed but uninfected (HEU) had increased mortality, morbidity and undernutrition compared with children who were HIV-unexposed. Scale-up of ART has led… read more here.
Keywords: exposed uninfected; health; children heu; evidence ... See more keywords
Pharmacokinetics and pharmacodynamics of adult dolutegravir tablets in treatment-experienced children with HIV weighing at least 20 kg.
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DOI: 10.1097/qad.0000000000003576
Abstract: OBJECTIVE Limited pharmacokinetic/pharmacodynamic data are a barrier to the well tolerated scale-up of dolutegravir-based antiretroviral therapy (ART) in children. We examined the pharmacokinetic/pharmacodynamic of the adult film-coated dolutegravir 50 mg tablets in children with HIV infection… read more here.
Keywords: hiv weighing; weighing least; experienced children; children hiv ... See more keywords
Association between HIV and cytomegalovirus and neurocognitive outcomes among children with HIV
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DOI: 10.1097/qad.0000000000004000
Abstract: Objectives: Children with HIV may experience adverse neurocognitive outcomes despite antiretroviral therapy (ART). Cytomegalovirus (CMV) is common in children with HIV. Among children on ART, we examined the influences of early HIV viral load and… read more here.
Keywords: pre art; load; cmv; children hiv ... See more keywords
Infectious morbidity among children HIV-exposed uninfected in South Africa: elevated risk in infancy but not thereafter.
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DOI: 10.1097/qad.0000000000004358
Abstract: BACKGROUND Increased risk of infectious morbidity and hospitalisation has been reported during infancy among children HIV-exposed uninfected (CHEU) compared to children HIV-unexposed uninfected (CHUU). However, data on risks beyond infancy are limited. METHODS We enrolled… read more here.
Keywords: risk; children hiv; infectious morbidity; cause hospitalisation ... See more keywords
Effect of Dolutegravir and multi-month dispensing on viral suppression among children with HIV.
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DOI: 10.1097/qai.0000000000003190
Abstract: BACKGROUND Few studies in sub-Saharan Africa have assessed the impact of multi-month dispensing (MMD) of antiretroviral therapy (ART) and dolutegravir (DTG) beyond clinical trials among children with HIV (CWHIV). We assessed the effect of the… read more here.
Keywords: month dispensing; effect; among children; dtg ... See more keywords
Survival and health of children who are HIV-exposed uninfected: study protocol for the CHERISH (Children HIV-Exposed Uninfected - Research to Inform Survival and Health) dynamic, prospective, maternal-child cohort study
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DOI: 10.1136/bmjopen-2022-070465
Abstract: Introduction CHERISH is designed to establish a long-term sustainable system for measurement of in utero and postnatal exposures and outcomes in children who are HIV-exposed uninfected (HEU) and HIV-unexposed to compare survival, hospitalisation, growth and… read more here.
Keywords: exposed uninfected; health; survival health; hiv exposed ... See more keywords
Structural brain differences in school-aged children who are HIV-exposed uninfected
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DOI: 10.1186/s12916-025-04332-3
Abstract: Antiretroviral therapy (ART) has dramatically reduced perinatal HIV transmission, leading to a growing population of children who are HIV-exposed but uninfected (CHEU). While the neuroanatomic developmental impacts of in utero HIV and ART exposure have… read more here.
Keywords: brain; hiv exposed; children hiv; language ... See more keywords
Talking to children about their HIV diagnosis: a discussion rooted in different global perspectives.
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DOI: 10.12968/bjon.2022.31.1.s4
Abstract: An online meeting was arranged with four professionals representing four countries to debate current practices and future steps in naming HIV to children (disclosing HIV status). This article considers the evidence and reports on the… read more here.
Keywords: hiv; diagnosis; hiv diagnosis; naming hiv ... See more keywords
Estimating the impact of alternative programmatic cotrimoxazole strategies on mortality among children born to mothers with HIV: A modelling study
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DOI: 10.1371/journal.pmed.1004334
Abstract: Background World Health Organization (WHO) guidelines recommend cotrimoxazole prophylaxis for children who are HIV-exposed until infection is excluded and vertical transmission risk has ended. While cotrimoxazole has benefits for children with HIV, there is no… read more here.
Keywords: cotrimoxazole strategies; hiv exposed; mortality; children hiv ... See more keywords