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   Articles with "chimera" as a keyword



Antitumor Activity of a Bispecific Chimera Targeting EGFR and Met in Gefitinib‐Resistant Non‐Small Cell Lung Cancer

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202402884

Abstract: Non‐small cell lung cancers (NSCLC) frequently acquire resistance to tyrosine kinase inhibitors (TKI) due to epidermal growth factor receptor (EGFR) mutation or activation of the bypass pathway involving mesenchymal‐epithelial transition factor (Met). To address this… read more here.

Keywords: non small; egfr met; chimera; small cell ... See more keywords

Congenital adrenal hyperplasia due to two rare CYP21A2 variant alleles, including a novel attenuated CYP21A1P/CYP21A2 chimera.

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recommendations! Published in 2023 at "Molecular genetics & genomic medicine"

DOI: 10.1002/mgg3.2195

Abstract: BACKGROUND Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase (21OH) deficiency is an autosomal recessive inborn error of cortisol biosynthesis, with varying degrees of aldosterone production. There is a continuum of phenotypes which generally correlate with… read more here.

Keywords: chimera; cyp21a2; cyp21a1p cyp21a2; cah ... See more keywords

Development of a biosensing platform based on a laccase-hydrophobin chimera

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recommendations! Published in 2019 at "Applied Microbiology and Biotechnology"

DOI: 10.1007/s00253-019-09678-2

Abstract: A simple and stable immobilization of a laccase from Pleurotus ostreatus was obtained through genetic fusion with a self-assembling and adhesive class I hydrophobin. The chimera protein was expressed in Pichia pastoris and secreted into… read more here.

Keywords: laccase; hydrophobin chimera; platform; chimera ... See more keywords

Chimera states and information transfer in interacting populations of map-based neurons

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recommendations! Published in 2024 at "Neural Computing and Applications"

DOI: 10.1007/s00521-024-10050-3

Abstract: We investigate the synchronization behavior and the emergence of chimera states in a system of two interacting populations of maps possessing chaotic neural-like dynamics. We characterize four collective states on the space of coupling parameters… read more here.

Keywords: states information; chimera; population; interacting populations ... See more keywords

From collective oscillation to chimera state in a nonlocally coupled excitable system

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recommendations! Published in 2018 at "Nonlinear Dynamics"

DOI: 10.1007/s11071-017-3977-0

Abstract: Chimera states, which consist of coexisting domains of spatially coherent and incoherent dynamics, have been widely found in nonlocally coupled oscillatory systems. We demonstrate that chimera states can emerge from excitable systems under nonlocal coupling… read more here.

Keywords: nonlocally coupled; collective oscillation; chimera; chimera states ... See more keywords

Chimera states in bipartite networks of FitzHugh–Nagumo oscillators

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recommendations! Published in 2017 at "Frontiers of Physics"

DOI: 10.1007/s11467-017-0737-z

Abstract: Chimera states consisting of spatially coherent and incoherent domains have been observed in different topologies such as rings, spheres, and complex networks. In this paper, we investigate bipartite networks of nonlocally coupled FitzHugh–Nagumo (FHN) oscillators… read more here.

Keywords: networks fitzhugh; bipartite networks; fitzhugh nagumo; chimera ... See more keywords

ERK-independent African Green monkey pluripotent stem cells in a putative chimera-competent state.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.01.037

Abstract: Generating human organs inside interspecies chimeras might one day produce patient-specific organs for clinical applications, but further advances in identifying human chimera-competent pluripotent stem (PS) cells are needed. Moreover, the potential for human PS cells… read more here.

Keywords: chimera competent; stem cells; chimera; pluripotent ... See more keywords

A novel molecular chaperone GroEL2 from Rhodococcus ruber and its fusion chimera with nitrile hydratase for co-enhanced activity and stability

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recommendations! Published in 2018 at "Chemical Engineering Science"

DOI: 10.1016/j.ces.2018.07.045

Abstract: Abstract Rhodococcus ruber harboring intracellular nitrile hydratase (NHase) is widely used in large-scale acrylamide production. Transcriptome analyses of R. ruber under urea induction and heat shock revealed the novel chaperones GroEL2 and GroES. M. jannaschii… read more here.

Keywords: rhodococcus ruber; groel2; chimera; nhase ... See more keywords

The emergence of chimera states in a network of nephrons

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recommendations! Published in 2020 at "Chinese Journal of Physics"

DOI: 10.1016/j.cjph.2019.10.024

Abstract: Abstract The kidney plays an essential role in our body, mainly by controlling secretion and reabsorption of water and salts. The kidneys consist of a large number of nephrons which are the functional units of… read more here.

Keywords: network; emergence chimera; chimera state; chimera ... See more keywords

Robust mucosal and systemic responses against HTLV‐1 by delivery of multi‐epitope vaccine in PLGA nanoparticles

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recommendations! Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"

DOI: 10.1016/j.ejpb.2018.11.003

Abstract: &NA; In this investigation, the immunogenicity of HTLV‐1 fusion epitope‐loaded PLGA nanoparticles (NPs) was assessed in the absence or presence of co‐encapsulated CpG ODN adjuvant, in a mice model. For this purpose, the multi‐epitope chimera… read more here.

Keywords: plga nanoparticles; chimera; responses htlv; vaccine ... See more keywords

Increased severity of the CHIMERA model induces acute vascular injury, sub-acute deficits in memory recall, and chronic white matter gliosis

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recommendations! Published in 2020 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2019.113116

Abstract: Traumatic brain injury (TBI) is a leading cause of death and disability in modern societies. Diffuse axonal and vascular injury are nearly universal consequences of mechanical energy impacting the head and contribute to disability throughout… read more here.

Keywords: matter; matter gliosis; chimera; injury ... See more keywords