Articles with "chimera" as a keyword



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Congenital adrenal hyperplasia due to two rare CYP21A2 variant alleles, including a novel attenuated CYP21A1P/CYP21A2 chimera.

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Published in 2023 at "Molecular genetics & genomic medicine"

DOI: 10.1002/mgg3.2195

Abstract: BACKGROUND Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase (21OH) deficiency is an autosomal recessive inborn error of cortisol biosynthesis, with varying degrees of aldosterone production. There is a continuum of phenotypes which generally correlate with… read more here.

Keywords: chimera; cyp21a2; cyp21a1p cyp21a2; cah ... See more keywords
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Development of a biosensing platform based on a laccase-hydrophobin chimera

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Published in 2019 at "Applied Microbiology and Biotechnology"

DOI: 10.1007/s00253-019-09678-2

Abstract: A simple and stable immobilization of a laccase from Pleurotus ostreatus was obtained through genetic fusion with a self-assembling and adhesive class I hydrophobin. The chimera protein was expressed in Pichia pastoris and secreted into… read more here.

Keywords: laccase; hydrophobin chimera; platform; chimera ... See more keywords
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From collective oscillation to chimera state in a nonlocally coupled excitable system

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Published in 2018 at "Nonlinear Dynamics"

DOI: 10.1007/s11071-017-3977-0

Abstract: Chimera states, which consist of coexisting domains of spatially coherent and incoherent dynamics, have been widely found in nonlocally coupled oscillatory systems. We demonstrate that chimera states can emerge from excitable systems under nonlocal coupling… read more here.

Keywords: nonlocally coupled; collective oscillation; chimera; chimera states ... See more keywords
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Chimera states in bipartite networks of FitzHugh–Nagumo oscillators

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Published in 2017 at "Frontiers of Physics"

DOI: 10.1007/s11467-017-0737-z

Abstract: Chimera states consisting of spatially coherent and incoherent domains have been observed in different topologies such as rings, spheres, and complex networks. In this paper, we investigate bipartite networks of nonlocally coupled FitzHugh–Nagumo (FHN) oscillators… read more here.

Keywords: networks fitzhugh; bipartite networks; fitzhugh nagumo; chimera ... See more keywords
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ERK-independent African Green monkey pluripotent stem cells in a putative chimera-competent state.

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Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.01.037

Abstract: Generating human organs inside interspecies chimeras might one day produce patient-specific organs for clinical applications, but further advances in identifying human chimera-competent pluripotent stem (PS) cells are needed. Moreover, the potential for human PS cells… read more here.

Keywords: chimera competent; stem cells; chimera; pluripotent ... See more keywords
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A novel molecular chaperone GroEL2 from Rhodococcus ruber and its fusion chimera with nitrile hydratase for co-enhanced activity and stability

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Published in 2018 at "Chemical Engineering Science"

DOI: 10.1016/j.ces.2018.07.045

Abstract: Abstract Rhodococcus ruber harboring intracellular nitrile hydratase (NHase) is widely used in large-scale acrylamide production. Transcriptome analyses of R. ruber under urea induction and heat shock revealed the novel chaperones GroEL2 and GroES. M. jannaschii… read more here.

Keywords: rhodococcus ruber; groel2; chimera; nhase ... See more keywords
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The emergence of chimera states in a network of nephrons

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Published in 2020 at "Chinese Journal of Physics"

DOI: 10.1016/j.cjph.2019.10.024

Abstract: Abstract The kidney plays an essential role in our body, mainly by controlling secretion and reabsorption of water and salts. The kidneys consist of a large number of nephrons which are the functional units of… read more here.

Keywords: network; emergence chimera; chimera state; chimera ... See more keywords
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Robust mucosal and systemic responses against HTLV‐1 by delivery of multi‐epitope vaccine in PLGA nanoparticles

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Published in 2018 at "European Journal of Pharmaceutics and Biopharmaceutics"

DOI: 10.1016/j.ejpb.2018.11.003

Abstract: &NA; In this investigation, the immunogenicity of HTLV‐1 fusion epitope‐loaded PLGA nanoparticles (NPs) was assessed in the absence or presence of co‐encapsulated CpG ODN adjuvant, in a mice model. For this purpose, the multi‐epitope chimera… read more here.

Keywords: plga nanoparticles; chimera; responses htlv; vaccine ... See more keywords
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Increased severity of the CHIMERA model induces acute vascular injury, sub-acute deficits in memory recall, and chronic white matter gliosis

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Published in 2020 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2019.113116

Abstract: Traumatic brain injury (TBI) is a leading cause of death and disability in modern societies. Diffuse axonal and vascular injury are nearly universal consequences of mechanical energy impacting the head and contribute to disability throughout… read more here.

Keywords: matter; matter gliosis; chimera; injury ... See more keywords
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Major Histocompatibilty Complex-Restricted Adaptive Immune Responses to CT26 Colon Cancer Cell Line in Mixed Allogeneic Chimera.

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Published in 2017 at "Transplantation proceedings"

DOI: 10.1016/j.transproceed.2017.03.011

Abstract: BACKGROUND Although the induction of mixed allogeneic chimera shows promising clinical tolerance results in organ transplantation, its clinical relevance as an anti-cancer therapy is yet unknown. We introduced a mixed allogenic chimera setting with the… read more here.

Keywords: cancer; chimera; mixed allogeneic; cancer cell ... See more keywords
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Bifunctional chimera for ligand-directed photo-degradation of oncogenic microRNA.

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Published in 2023 at "Chemical communications"

DOI: 10.1039/d2cc06687d

Abstract: Targeted inhibition of oncogenic microRNAs provides a promising anti-cancer approach. Here, we report a bifunctional chimera for ligand-directed regulation of target oncogenic precursor microRNA through photo-degradation. Chimeric TGP-210-Ppa with photosensitizer pyropheophorbide a (Ppa) linked with… read more here.

Keywords: chimera; photo degradation; ligand directed; chimera ligand ... See more keywords