Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC).
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DOI: 10.1039/d2cc00272h
Abstract: We developed a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8). The PROTAC induced degradation of HDAC8 without affecting the levels of other HDACs in cellular assays, and inhibited the… read more here.
Keywords: targeting chimera; degradation; protac; proteolysis targeting ... See more keywords