The metabolic fate of fenclozic acid in chimeric mice with a humanized liver
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DOI: 10.1007/s00204-018-2274-0
Abstract: The metabolic fate of the human hepatotoxin fenclozic acid ([2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetic acid) (Myalex) was studied in normal and bile-cannulated chimeric mice with a humanized liver, following oral administration of 10 mg/kg. This in vivo animal model was… read more here.
Keywords: mice humanized; chimeric mice; fenclozic acid; acid ... See more keywords
Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-019-01558-w
Abstract: Background and aimsThe clinical course and responsiveness to antiviral treatments differs among hepatitis B virus (HBV) genotypes. However, the cause of these differences is unclear. In the present study, we compared mRNA expression profiles in… read more here.
Keywords: infection; genotype infection; hbv genotype; chimeric mice ... See more keywords
CSF2-dependent monocyte education in the pathogenesis of ANCA-induced glomerulonephritis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-221984
Abstract: Objectives Myeloid cell activation by antineutrophil cytoplasmic antibody (ANCA) is pivotal for necrotising vasculitis, including necrotising crescentic glomerulonephritis (NCGN). In contrast to neutrophils, the contribution of classical monocyte (CM) and non-classical monocyte (NCM) remains poorly… read more here.
Keywords: chimeric mice; mice; csf2; glomerulonephritis ... See more keywords
Characterization and Prevention of Hypovitaminosis C in Chimeric Mice with Humanized Livers.
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DOI: 10.30802/aalas-cm-22-000027
Abstract: Humanized liver chimeric mice (PXB-mice) are generated by the transplantation of human hepatocytes into mice that have severe combined immunodeficiency and express an albumin-promoted urokinase-type plasminogen activator (cDNA-uPA/SCID) transgene. Human hepatocytes cannot synthesize ascorbic acid… read more here.
Keywords: chimeric mice; nonsupplemented pxb; hypovitaminosis; pxb mice ... See more keywords
Simultaneous measurement of mouse and human albumin in chimeric mice with humanized livers.
Sign Up to like & getrecommendations! Published in 2022 at "Bioanalysis"
DOI: 10.4155/bio-2021-0250
Abstract: Background: The degree of human hepatocyte replacement in chimeric mice with humanized liver has previously been shown to correlate with human plasma albumin measurements. However, there are no reports that directly compare the remaining endogenous mouse albumin with the newly… read more here.
Keywords: chimeric mice; mouse; human albumin; mice ... See more keywords