Beyond Proteolysis-Targeting Chimeric Molecules: Designing Heterobifunctional Molecules Based on Functional Effectors.
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DOI: 10.1021/acs.jmedchem.2c00316
Abstract: In recent years, with the successful development of proteolysis-targeting chimeric molecules (PROTACs), the potential of heterobifunctional molecules to contribute to reenvisioning drug design, especially small-molecule drugs, has been increasingly recognized. Inspired by PROTACs, diverse heterobifunctional… read more here.
Keywords: targeting chimeric; heterobifunctional molecules; chimeric molecules; proteolysis targeting ... See more keywords
Protein Targeting Chimeric Molecules Specific for Bromodomain and Extra-terminal Motif Family Proteins are Active Against Pre-Clinical Models of Multiple Myeloma
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DOI: 10.1038/s41375-018-0044-x
Abstract: Bromodomain and extraterminal (BET) domain containing protein (BRD)-4 modulates the expression of oncogenes such as c-myc, and is a promising therapeutic target in diverse cancer types. We performed pre-clinical studies in myeloma models with bi-functional… read more here.
Keywords: protein; targeting chimeric; protein targeting; pre clinical ... See more keywords