Functional Analysis of Human Hepatocytes Isolated From Chimeric Mouse Liver.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.06.035
Abstract: Chimeric mice with humanized liver were first established by transplanting primary human hepatocytes (PHHs) isolated from a Japanese 27-year-old donor into complementary DNA-urokinase-type plasminogen activator/severe combined immunodeficiency mice. The PHHs from the Japanese donor increased… read more here.
Keywords: analysis human; chimeric mouse; human hepatocytes; mouse liver ... See more keywords
Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Toxicologic Pathology"
DOI: 10.1177/01926233211027474
Abstract: Porphyrinogenic compounds are known to induce porphyria-mediated hepatocellular injury and subsequent regenerative proliferation in rodents, ultimately leading to hepatocellular tumor induction. However, an appropriate in vivo experimental model to evaluate an effect of porphyrinogenic compounds… read more here.
Keywords: porphyria mediated; mouse humanized; chimeric mouse; model ... See more keywords
Development of a Method for the In Vivo Generation of Allogeneic Hearts in Chimeric Mouse Embryos
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021163
Abstract: Worldwide, there is a great gap between the demand and supply of organs for transplantations. Organs generated from the patients’ cells would not only solve the problem of transplant availability but also overcome the complication… read more here.
Keywords: chimeric mouse; mouse embryos; hearts chimeric; method ... See more keywords