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Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00177
Abstract: The main challenge in inhibiting protein-protein interactions (PPI) for therapeutic purposes is designing molecules that bind specifically to the interaction hotspots. Adding to the complexity, such hotspots can be within both structured and disordered interaction…
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Keywords:
interaction;
structured disordered;
interaction hotspots;
peptide inhibitors ... See more keywords
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3
Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.781270
Abstract: The discovery of circular RNAs and exploration of their biological functions are increasingly attracting attention in cell bio-sciences. Owing to their unique characteristics of being highly conserved, having a relatively longer half-life, and involvement in…
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Keywords:
circrna update;
update mechanisms;
proteins encoded;
chimeric peptides ... See more keywords
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1
Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012700
Abstract: Recently, mixed opioid/NOP agonists came to the spotlight for their favorable functional profiles and promising outcomes in clinical trials as novel analgesics. This study reports on two novel chimeric peptides incorporating the fragment Tyr-c[D-Lys-Phe-Phe]Asp-NH2 (RP-170),…
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Keywords:
synthesis biological;
opioid nop;
activity molecular;
biological activity ... See more keywords