A case of 46,XX/46,XX chimerism in a phenotypically normal woman
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DOI: 10.1007/s00414-020-02296-y
Abstract: Chimerism is the presence of two genetically different cell lines within a single organism, which is rarely observed in humans. Usually, chimerism in the human body is revealed by the finding of an abnormal phenotype… read more here.
Keywords: phenotypically normal; chimerism; case chimerism; chimerism phenotypically ... See more keywords
Donor Lymphocyte Infusion from G-CSF-Primed, Unmanipulated Whole Blood Is Safe and Improves Chimerism in HLA-Matched and Haploidentical Transplantation
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DOI: 10.1016/j.bbmt.2018.12.312
Abstract: Introduction Donor lymphocyte infusion (DLI) is a useful therapy for mixed chimerism (MC) and measurable residual disease (MRD) after allogeneic transplantation (HSCT). Multiple DLI products can be obtained through apheresis and cryopreservation, but their costs… read more here.
Keywords: blood; csf; whole blood; chimerism ... See more keywords
Host T-Cells Contribute to Immune Reconstitution and Improved Outcome in Recipients of CD34 Selected T-Cell Depleted Allografts (TCD HCT) with Full Hematopoietic Cell but Persistent Mixed T-Cell Chimerism
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DOI: 10.1016/j.bbmt.2019.12.408
Abstract: Background Isolated mixed T-cell chimerism in otherwise fully engrafted recipients of TCDHCT has been associated, in some series, with risk of graft rejection or relapses and an indication for DLI. Thereto, we have analyzed the… read more here.
Keywords: mixed cell; chimerism; cell chimerism; host ... See more keywords
Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates
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DOI: 10.1016/j.healun.2021.01.430
Abstract: Purpose Our group has achieved cardiac allograft tolerance in non-human primates (NHPs) via hematopoietic cellular chimerism mediated through allogeneic bone marrow (BM) and kidney co-transplantation after non-myeloablative conditioning. This form of tolerance is believed to… read more here.
Keywords: bone marrow; donor mhc; mhc chimerism; chimerism ... See more keywords
Late chimerical status after bone marrow transplantation in severe aplastic anemia according to two different preparatory regimens
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DOI: 10.1016/j.htct.2017.11.011
Abstract: Background This study investigated the influence of two conditioning regimens on the chimerical status of 104 patients with acquired severe aplastic anemia. Methods Patients were monitored for at least 18 months after related bone marrow… read more here.
Keywords: recovery; chimerical status; chimerism; group ... See more keywords
Early achievement of full donor chimerism after allogeneic hematopoietic stem cell transplantation predicts lower relapse risk in patients with acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Chinese Medical Association"
DOI: 10.1016/j.jcma.2018.06.005
Abstract: Background: Acute lymphoblastic leukemia (ALL) remains one of the most difficult‐to‐cure hematological malignancies. Allogeneic hematopoietic stem cell transplantation (HSCT) provides curative potential but a substantial proportion of patients eventually will relapse. It is unknown if… read more here.
Keywords: chimerism; donor chimerism; relapse; acute lymphoblastic ... See more keywords
Tri-allelic expression of HLA gene in 46,XX/46,XY chimerism.
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DOI: 10.1016/j.trim.2018.12.004
Abstract: INTRODUCTION Chimerism is defined as coexistence of different cell lines in an individual. 46,XX/46,XY chimerism is very rare and exhibits broad range of clinical phenotypes. Most cases are detected at infancy or younger age due… read more here.
Keywords: hla alleles; chimerism; hla; expression hla ... See more keywords
Systematic comparison of donor chimerism in peripheral blood and bone marrow after hematopoietic stem cell transplantation
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DOI: 10.1038/bcj.2017.42
Abstract: Incomplete donor chimerism (DC) after hematopoietic stem cell transplantation (HSCT) is associated with reduced overall and disease-free survival and decreasing DC can precede overt relapse of malignant diseases.1, 2 Sensitive chimerism quantification may therefore allow… read more here.
Keywords: chimerism; donor chimerism; cell transplantation; stem cell ... See more keywords
Quantitative chimerism in CD3-negative mononuclear cells predicts prognosis in acute myeloid leukemia patients after hematopoietic stem cell transplantation
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DOI: 10.1038/s41375-019-0624-4
Abstract: Relapse is a major complication of acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (SCT). The objective of our study was to evaluate chimerism monitoring on the CD3-negative mononuclear cells by RQ-PCR to… read more here.
Keywords: negative mononuclear; chimerism; relapse; cell ... See more keywords
Combined kidney and hematopoeitic cell transplantation to induce mixed chimerism and tolerance
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DOI: 10.1038/s41409-019-0603-4
Abstract: Based on preclinical studies, combined kidney and hematopoietic cell transplantation was performed on fully HLA matched and haplotype matched patients at the Stanford University Medical Center. The object of the studies was to induce mixed… read more here.
Keywords: mixed chimerism; tolerance; combined kidney; chimerism ... See more keywords
Central tolerance promoted by cell chimerism
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214989119
Abstract: Historically, successful allotransplantation was only achieved by utilizing powerful immunosuppressive drugs that were exposing the patient to severe opportunistic infections. The thymus of the transplant recipient renders such therapy obligatory as it constitutively blocks self-reactive… read more here.
Keywords: tolerance promoted; cell; chimerism; donor ... See more keywords