Effect of Dietary Intake on the Pharmacokinetics of the Multitargeted Receptor Tyrosine Kinase Inhibitor Famitinib: Results From a Phase 1 Study in Healthy Chinese Participants
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DOI: 10.1002/cpdd.1238
Abstract: Famitinib is a tyrosine kinase inhibitor under clinical investigation for the treatment of solid tumors. Here, a 3‐period crossover trial investigated the effect of high‐fat or low‐fat food intake on the single‐dose pharmacokinetic properties of… read more here.
Keywords: chinese participants; kinase inhibitor; tyrosine kinase; intake ... See more keywords
Association between triglyceride glucose-related markers and the risk of metabolic-associated fatty liver disease: a cross-sectional study in healthy Chinese participants
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DOI: 10.1136/bmjopen-2022-070189
Abstract: Objectives This study aimed to evaluate the performance of the triglyceride glucose (TyG) index and its related markers in predicting metabolic-associated fatty liver disease (MAFLD) in healthy Chinese participants. Design This was a cross-sectional study.… read more here.
Keywords: tyg bmi; metabolic associated; chinese participants; triglyceride glucose ... See more keywords
The Naturalness Bias Influences Drug and Vaccine Decisions across Cultures
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DOI: 10.1177/0272989x221140803
Abstract: Past research with North American participants has demonstrated a naturalness bias in the medical context: people prefer natural drugs to synthetic drugs under a variety of situations. Does such a bias exist in other countries… read more here.
Keywords: across cultures; naturalness bias; chinese participants; vaccine ... See more keywords
Safety, Tolerability, and Pharmacokinetics of Benralizumab: A Phase 1, Randomized, Single-Blind Study of Healthy Chinese Participants
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DOI: 10.2147/dddt.s392155
Abstract: Purpose Biological therapies targeting eosinophils have been shown to be effective in treating patients with severe eosinophilic asthma. Benralizumab (Fasenra®, AstraZeneca) is a humanized monoclonal antibody binding to the alpha subunit of the interleukin-5 receptor,… read more here.
Keywords: pharmacokinetics benralizumab; safety; chinese participants; healthy chinese ... See more keywords
Culture Impacts the Neural Response to Perceiving Outgroups Among Black and White Faces
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DOI: 10.3389/fnhum.2019.00143
Abstract: Outgroup members (e.g., individuals whose racial identity differs from perceivers’) are stigmatized in Eastern and Western cultures. However, it remains an open question how specific cultural influences affect stigmatization. In this study, we assessed whether… read more here.
Keywords: black white; white american; response; intergroup contact ... See more keywords