Establishment of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Immunosuppressant levels in the Peripheral Blood Mononuclear Cells of Chinese Renal Transplant Recipients.
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DOI: 10.1097/ftd.0000000000000765
Abstract: BACKGROUND Monitoring immunosuppressant levels, such as mycophenolic acid (MPA), cyclosporin A (CsA), and tacrolimus (TAC), in peripheral blood mononuclear cells (PBMCs) could be useful in organ transplant patients administered individualized therapy. The authors developed an… read more here.
Keywords: blood mononuclear; transplant; peripheral blood; immunosuppressant levels ... See more keywords
Estimation of Mycophenolic Acid Exposure in Chinese Renal Transplant Patients by a Joint Deep Learning Model
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DOI: 10.1097/ftd.0000000000001020
Abstract: Supplemental Digital Content is Available in the Text. Background: To predict mycophenolic acid (MPA) exposure in renal transplant recipients using a deep learning model based on a convolutional neural network with bilateral long short-term memory… read more here.
Keywords: chinese renal; transplant patients; mycophenolic acid; model ... See more keywords
Genomewide association study identifies a novel variant associated with tacrolimus trough concentration in Chinese renal transplant recipients
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DOI: 10.1111/cts.13388
Abstract: Tacrolimus (TAC) is an immunosuppressant widely used in kidney transplantation. TAC displays considerable interindividual variability in pharmacokinetics (PKs). Genetic and clinical factors play important roles in TAC PKs. We enrolled a total of 251 Chinese… read more here.
Keywords: chinese renal; genomewide association; renal transplant; transplant recipients ... See more keywords
PXR haplotype clusters will affect the pharmacokinetics of ciclosporin in Chinese renal transplant recipients
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DOI: 10.1111/jphp.13206
Abstract: PXR was reported to be the key nuclear receptor regulating the expression of metabolizing enzymes and transporters. The aim of this study was to evaluate the influence of PXR haplotype clusters on ciclosporin concentration in… read more here.
Keywords: pxr haplotype; haplotype clusters; renal transplant; transplant recipients ... See more keywords