Pharmacokinetics and Bioequivalence of a Generic and a Branded Pazopanib Tablet in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1096
Abstract: This study aimed to evaluate the bioequivalence of two pazopanib tablet formulations in healthy Chinese subjects. A randomized, open‐label, single‐dose, two‐period, two‐sequence, crossover study was conducted under fasting conditions. A total of 32 eligible subjects… read more here.
Keywords: pazopanib tablet; chinese subjects; tablet; generic branded ... See more keywords
Pharmacokinetic and Bioequivalence Study of Eldecalcitol Soft Capsules in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1159
Abstract: Eldecalcitol is a novel active vitamin D3 1,25(OH)2D3 derivative used in the treatment of osteoporosis. To investigate and compare the pharmacokinetic and bioequivalent profiles of two eldecalcitol soft capsule formulations at a single dose of… read more here.
Keywords: chinese subjects; fed conditions; eldecalcitol soft; soft capsules ... See more keywords
A Single‐dose, Two‐Period Crossover Bioequivalence Study Comparing Two Liraglutide Formulations in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1187
Abstract: Liraglutide, a glucagon‐like peptide 1 receptor agonist, is indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes. The original liraglutide products are costly, which limits patient… read more here.
Keywords: single dose; chinese subjects; liraglutide formulations; bioequivalence ... See more keywords
Pharmacokinetics and Bioequivalence of the Lubiprostone Capsule in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1212
Abstract: A pharmacokinetic (PK) study and a bioequivalence (BE) study were conducted to investigate the PK characteristics and safety of lubiprostone in healthy Chinese subjects and to evaluate the BE between the test and the reference… read more here.
Keywords: single dose; state; chinese subjects; lubiprostone ... See more keywords
Bioequivalence and Food Effect Assessment Between 2 Oral Tablet Formulations of Rivaroxaban 20 mg in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1511
Abstract: To evaluate the bioequivalence and safety of oral rivaroxaban tablets between a test formulation and a reference formulation in healthy Chinese subjects, a randomized, open, 2‐formulation, 4‐cycle, complete repeat crossover study was conducted under both… read more here.
Keywords: formulation; rivaroxaban; healthy chinese; chinese subjects ... See more keywords
Bioequivalence and Tolerability of 2 Lurasidone Formulations: A Randomized, Single‐Dose, 2‐Period, Crossover Study in Healthy Chinese Subjects Under Fasting and Fed Conditions
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DOI: 10.1002/cpdd.1529
Abstract: Lurasidone is utilized in the treatment of schizophrenia and bipolar depression in adults and adolescents. In this work, a randomized, single‐dose, 2‐period crossover study was designed and conducted to evaluate the bioequivalence and safety of… read more here.
Keywords: single dose; healthy chinese; lurasidone; chinese subjects ... See more keywords
Pharmacokinetic Profile of a Generic Formulation of Sofosbuvir and Its Metabolite GS‐331007 in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.674
Abstract: Sofosbuvir is an NS5B nucleotide inhibitor for the treatment of hepatitis C viral infection. In this study the pharmacokinetics (PK) and safety of single and multiple doses of generic sofosbuvir were investigated in healthy Chinese… read more here.
Keywords: healthy chinese; chinese subjects; generic formulation; formulation sofosbuvir ... See more keywords
Serum amylase activity altered by the ABO blood group system in Chinese subjects
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DOI: 10.1002/jcla.22883
Abstract: The underlying interactions between ABO blood group antigens and pancreatic exocrine tissue have been demonstrated, and serum amylase was synthesized by pancreatic ductal cells. Thus, we investigated the link between ABO blood type and serum… read more here.
Keywords: blood group; serum amylase; amylase activity; chinese subjects ... See more keywords
Safety, Tolerability and Pharmacokinetics of Single Ascending and Multiple Oral Doses of Tegoprazan in Healthy Chinese Subjects
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DOI: 10.1007/s40261-020-00986-4
Abstract: Background and Objectives Tegoprazan is one of the potassium-competitive acid blockers (P-CABs). It exhibits its anti-secretory effects by competitively and reversibly blocking the availability of K + of the H + , K + -ATPase.… read more here.
Keywords: healthy chinese; administration; safety; single ascending ... See more keywords
Short-term Safety, Tolerability, and Pharmacokinetics of MRX-I, an Oxazolidinone Antibacterial Agent, in Healthy Chinese Subjects.
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DOI: 10.1016/j.clinthera.2017.12.017
Abstract: PURPOSE This study was designed to evaluate the safety and pharmacokinetic profiles of MRX-I tablet, an oxazolidinone antibacterial agent, in healthy Chinese subjects. METHODS The study was composed of 3 sequential periods. Period 1 was… read more here.
Keywords: healthy chinese; study; oxazolidinone antibacterial; chinese subjects ... See more keywords
Pharmacokinetics, Tolerability, and Bioequivalence of Two Formulations of Rotigotine in Healthy Chinese Subjects.
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DOI: 10.1016/j.clinthera.2018.05.009
Abstract: PURPOSE The pharmacokinetic (PK) profile of the rotigotine transdermal patch is well characterized in Caucasian patients with Parkinson's disease (PD) but not in Chinese subjects. This article reports the PK variables, safety, and tolerability of… read more here.
Keywords: healthy chinese; unconjugated total; rotigotine healthy; rotigotine ... See more keywords