Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model.
Sign Up to like & getrecommendations! Published in 2017 at "Small"
DOI: 10.1002/smll.201603737
Abstract: Organ-on-a-chip platforms seek to recapitulate the complex microenvironment of human organs using miniaturized microfluidic devices. Besides modeling healthy organs, these devices have been used to model diseases, yielding new insights into pathophysiology. Hutchinson-Gilford progeria syndrome… read more here.
Keywords: progeria chip; biomechanical strain; chip model; strain ... See more keywords
Mechanical Induction of Osteoarthritis Traits in a Cartilage-on-a-Chip Model.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1693-2_14
Abstract: The present lack of effective therapies for osteoarthritis, the most diffused musculoskeletal disease, correlates with the absence of representative in vitro disease models. Microfabrication techniques and soft lithography allow the development of organs and tissues… read more here.
Keywords: cartilage chip; osteoarthritis; chip model; mechanical induction ... See more keywords
Electromechanical Stimulation of 3D Cardiac Microtissues in a Heart-on-Chip Model.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1693-2_9
Abstract: Modeling human cardiac tissues in vitro is essential to elucidate the biological mechanisms related to the heart physiopathology, possibly paving the way for new treatments. Organs-on-chips have emerged as innovative tools able to recreate tissue-specific… read more here.
Keywords: heart chip; heart; chip model; electromechanical stimulation ... See more keywords
Microwell-based pancreas-on-chip model enhances genes expression and functionality of rat islets of Langerhans
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110892
Abstract: Organ-on-chip technology is a promising tool for investigating physiological in vitro responses in drug screening development, and in advanced disease models. Within this framework, we investigated the behavior of rat islets of Langerhans in an… read more here.
Keywords: islets langerhans; chip model; rat islets; pancreas chip ... See more keywords
Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical therapeutic efficacy evaluation
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92264-2
Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and strongly correlates with the growing incidence of obesity and type II diabetes. We have developed a human-on-a-chip model composed of human hepatocytes and… read more here.
Keywords: chip model; efficacy; model; evaluation ... See more keywords
An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes
Sign Up to like & getrecommendations! Published in 2020 at "Slas Technology"
DOI: 10.1177/2472630320924999
Abstract: Development of efficient drugs and therapies for the treatment of inflammatory conditions in the intestine is often hampered by the lack of reliable, robust, and high-throughput in vitro and in vivo models. Current models generally… read more here.
Keywords: intestinal inflammation; chip model; intestine chip; modularity ... See more keywords